M7C9R0 · M7C9R0_CHEMY
- ProteinMultidrug resistance-associated protein 1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1459 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O = 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.
- 2',3'-cGAMP(in) + ATP + H2O = 2',3'-cGAMP(out) + ADP + phosphate + H+
- leukotriene C4(in) + ATP + H2O = leukotriene C4(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.
- sphing-4-enine 1-phosphate(in) + ATP + H2O = sphing-4-enine 1-phosphate(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | basolateral plasma membrane | |
Molecular Function | ABC-type xenobiotic transporter activity | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | glutathione transmembrane transporter activity |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMultidrug resistance-associated protein 1
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Testudinata > Testudines > Cryptodira > Durocryptodira > Americhelydia > Chelonioidea > Cheloniidae > Chelonia
Accessions
- Primary accessionM7C9R0
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 124-141 | Helical | ||||
Sequence: GVMLIFWFTALLCATIIF | ||||||
Transmembrane | 161-179 | Helical | ||||
Sequence: VTFYSYFVLVLIQLILSCF | ||||||
Transmembrane | 351-372 | Helical | ||||
Sequence: YLYTGLLFACACLQTLILHQYF | ||||||
Transmembrane | 399-418 | Helical | ||||
Sequence: VLAGVAVMILLVPVNAVMAM | ||||||
Transmembrane | 476-504 | Helical | ||||
Sequence: AYLAAAATFTWVCAPFLVALSTFAVYVLV | ||||||
Transmembrane | 516-540 | Helical | ||||
Sequence: FVSLALFNILRFPLNILPMVISSMV | ||||||
Transmembrane | 897-924 | Helical | ||||
Sequence: AIGLFVSFLSIFLFMCNHIAALASNYWL | ||||||
Transmembrane | 944-972 | Helical | ||||
Sequence: LGVYGALGMSQGIAVFGYSMAVSIGGIFA | ||||||
Transmembrane | 1026-1057 | Helical | ||||
Sequence: LFNVIGACIIILLATPIAAIIIPPLGLVYFFV |
Keywords
- Cellular component
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, domain, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 18-43 | Disordered | ||||
Sequence: DRRLRQTGPGPPFPTSLRAPPPAGEG | ||||||
Domain | 396-541 | ABC transmembrane type-1 | ||||
Sequence: GPSVLAGVAVMILLVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKEKVLGIRQEELKVLKKSAYLAAAATFTWVCAPFLVALSTFAVYVLVDKNNVLDAQKAFVSLALFNILRFPLNILPMVISSMVQ | ||||||
Domain | 571-799 | ABC transporter | ||||
Sequence: VKCSPLFVCGIVPREAELCVIYFSISFTVPEGSLIAIVGQVGCGKSSLLSALLGEMDKREGYVAVKGSVAYVPQQAWIQNAALKDNIIFGREMKESHYKRVIEACALLPDIEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYCNTDVYLFDDPLSAVDAHVGKHIFDKVIGPKGILKNKTRILVTHGVSYLPLMDTIIVMTDGKISEMGSYQELLKQDGAFAEFLRT | ||||||
Compositional bias | 839-866 | Polar residues | ||||
Sequence: RQLSNSSTYSGETGKSLNQTSTTELQKA | ||||||
Region | 839-870 | Disordered | ||||
Sequence: RQLSNSSTYSGETGKSLNQTSTTELQKAPAEK | ||||||
Domain | 904-1184 | ABC transmembrane type-1 | ||||
Sequence: FLSIFLFMCNHIAALASNYWLSLWTDDPIINGTQQHTHVRLGVYGALGMSQGIAVFGYSMAVSIGGIFASRHLHVGLLHSVLRSPMSFFERTPSGNLVNRFSKEMDTIDSVIPQIIKMFMGSLFNVIGACIIILLATPIAAIIIPPLGLVYFFVQRFYVATSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQTRFKQQSDLKVDENQKAYFPSIVANRWLAVRLECVGNCIVLFAALFAVIARNSLSPGLVGLSVSYSLQVTTYLNWLVRMSSEMET | ||||||
Domain | 1223-1455 | ABC transporter | ||||
Sequence: FRGYGLRYREDLDLVLKNINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGVNVAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFDKYSDEEIWTSLELAHLKNFVSSLPDKLNHECSEGGENISVGQRQLVCLARALLRKSKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYERVIVLDKGEIVECDSPANLLQKKGIFYSMAKD |
Sequence similarities
Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,459
- Mass (Da)161,942
- Last updated2013-05-29 v1
- Checksum58D6758CAB3E9438
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 839-866 | Polar residues | ||||
Sequence: RQLSNSSTYSGETGKSLNQTSTTELQKA |
Keywords
- Technical term