M7BTJ8 · M7BTJ8_CHEMY
- ProteinAmine oxidase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids2900 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H+
Cofactor
Note: Contains 1 topaquinone per subunit.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 2520 | Proton acceptor | ||||
Sequence: D | ||||||
Active site | 2605 | Schiff-base intermediate with substrate; via topaquinone | ||||
Sequence: Y |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Cellular Component | proteasome activator complex | |
Molecular Function | ATP binding | |
Molecular Function | copper ion binding | |
Molecular Function | histone H2AS1 kinase activity | |
Molecular Function | primary methylamine oxidase activity | |
Molecular Function | protein serine kinase activity | |
Molecular Function | quinone binding | |
Biological Process | amine metabolic process | |
Biological Process | protein phosphorylation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAmine oxidase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Testudinata > Testudines > Cryptodira > Durocryptodira > Americhelydia > Chelonioidea > Cheloniidae > Chelonia
Accessions
- Primary accessionM7BTJ8
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Modified residue | 2605 | 2',4',5'-topaquinone | ||||
Sequence: Y |
Post-translational modification
Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.
Keywords
- PTM
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, domain, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-30 | Disordered | ||||
Sequence: MQRQPAQVAPEQQARAGWSGAQREENEEIE | ||||||
Domain | 43-301 | Protein kinase | ||||
Sequence: LKSDMWTGRGSFKTVYKGLDTETTVEVAWCELQTRKLSKAERQRFSEEVEMLKGLQHPNIVRFYDSWKSAIKGQICIVLLSELMTSGTLKTYLKRFKEMKLKVLRCWSRQILKGLHFLHTRSPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEKYDEAVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGRKPNSFYKVKVPELKEIIEGCIRMNKAERYTIQDLLEHSFF | ||||||
Region | 422-456 | Disordered | ||||
Sequence: PPVPTTPQPSPPTPGSGDSVFGGTFPPEPEEPEAD | ||||||
Region | 639-659 | Disordered | ||||
Sequence: DGQGATRADGSPQPESLSPSA | ||||||
Region | 713-756 | Disordered | ||||
Sequence: SFSQTAVPGPQAGGSLLPTTPPRGGLGPLSTPRNSTAPTALPWS | ||||||
Compositional bias | 741-756 | Polar residues | ||||
Sequence: LSTPRNSTAPTALPWS | ||||||
Region | 817-1015 | Disordered | ||||
Sequence: GPTGLVEPAPRCSGTQEPTSSRVTGGWGPALAPQGLERSGTRESPLSSVRAPAVDSGLVSPCSLKPSSHLIVSESPAPGTAKARLSPINEEAKPQILGRFQVTTSKDPANSPLGQPSQSDREQSGPEPWEGVAGTSSQPSVPSSSALEGSTSSDSDSVPDTPVQDPDELLAEEGTPVALADSDQEGPAEGGAESPQQAV | ||||||
Compositional bias | 914-976 | Polar residues | ||||
Sequence: GRFQVTTSKDPANSPLGQPSQSDREQSGPEPWEGVAGTSSQPSVPSSSALEGSTSSDSDSVPD | ||||||
Compositional bias | 1094-1141 | Polar residues | ||||
Sequence: QRRLSKGSFNPSRRNSLQRLELSQPTGIMRRNSLSGSSTGSQEQRPSR | ||||||
Region | 1094-1142 | Disordered | ||||
Sequence: QRRLSKGSFNPSRRNSLQRLELSQPTGIMRRNSLSGSSTGSQEQRPSRG |
Sequence similarities
Belongs to the copper/topaquinone oxidase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length2,900
- Mass (Da)322,184
- Last updated2013-05-29 v1
- ChecksumCC000B41E3AFB4A2
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 741-756 | Polar residues | ||||
Sequence: LSTPRNSTAPTALPWS | ||||||
Compositional bias | 914-976 | Polar residues | ||||
Sequence: GRFQVTTSKDPANSPLGQPSQSDREQSGPEPWEGVAGTSSQPSVPSSSALEGSTSSDSDSVPD | ||||||
Compositional bias | 1094-1141 | Polar residues | ||||
Sequence: QRRLSKGSFNPSRRNSLQRLELSQPTGIMRRNSLSGSSTGSQEQRPSR |
Keywords
- Technical term