M7BSR4 · M7BSR4_CHEMY
- Protein6-pyruvoyl tetrahydrobiopterin synthase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids738 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
function
Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.
Catalytic activity
- (3R)-3-hydroxy-10'-apo-beta-carotenal + O2 = (3R)-hydroxy-beta-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedialThis reaction proceeds in the forward direction.
- (3R,6R)-3-hydroxy-10'-apo-alpha-carotenal + O2 = (3R,6R)-hydroxy-alpha-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedialThis reaction proceeds in the forward direction.
- 13-cis-lycopene + O2 = (3E,5E)-6,10-dimethylundeca-3,5,9-trien-2-one + 13-cis-10'-apo-lycopenalThis reaction proceeds in the forward direction.
- 5-cis-lycopene + O2 = (3E,5E)-6,10-dimethylundeca-3,5,9-trien-2-one + 5-cis-10'-apo-lycopenalThis reaction proceeds in the forward direction.
- all-trans-10'-apo-beta-carotenal + O2 = 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial + beta-iononeThis reaction proceeds in the forward direction.
- all-trans-zeaxanthin + 2 O2 = 2 (3R)-hydroxy-beta-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedialThis reaction proceeds in the forward direction.
- all-trans-zeaxanthin + O2 = (3R)-3-hydroxy-10'-apo-beta-carotenal + (3R)-hydroxy-beta-iononeThis reaction proceeds in the forward direction.
- beta-cryptoxanthin + O2 = (3R)-hydroxy-beta-ionone + all-trans-10'-apo-beta-carotenalThis reaction proceeds in the forward direction.
- lutein + O2 = (3R)-3-hydroxy-10'-apo-beta-carotenal + (3R,6R)-hydroxy-alpha-iononeThis reaction proceeds in the forward direction.
- lutein + O2 = (3R)-hydroxy-beta-ionone + (3R,6R)-3-hydroxy-10'-apo-alpha-carotenalThis reaction proceeds in the forward direction.
Cofactor
Note: Binds 1 Fe2+ ion per subunit.
Pathway
Cofactor biosynthesis; tetrahydrobiopterin biosynthesis; tetrahydrobiopterin from 7,8-dihydroneopterin triphosphate: step 1/3.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrion | |
Molecular Function | 6-pyruvoyltetrahydropterin synthase activity | |
Molecular Function | beta-carotene 15,15'-dioxygenase activity | |
Molecular Function | carotenoid dioxygenase activity | |
Molecular Function | metal ion binding | |
Biological Process | carotene catabolic process | |
Biological Process | retinal metabolic process | |
Biological Process | tetrahydrobiopterin biosynthetic process |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name6-pyruvoyl tetrahydrobiopterin synthase
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Testudinata > Testudines > Cryptodira > Durocryptodira > Americhelydia > Chelonioidea > Cheloniidae > Chelonia
Accessions
- Primary accessionM7BSR4
Proteomes
Subcellular Location
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length738
- Mass (Da)83,532
- Last updated2013-05-29 v1
- ChecksumD24B0AD258C2E985
Keywords
- Technical term