M7BP59 · M7BP59_CHEMY

Function

function

Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Pathway

Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site34-40GTP (UniProtKB | ChEBI)
Active site35Proton acceptor
Binding site35Mg2+ (UniProtKB | ChEBI)
Binding site35-38IMP (UniProtKB | ChEBI)
Binding site60-63IMP (UniProtKB | ChEBI)
Binding site62Mg2+ (UniProtKB | ChEBI)
Binding site62-64GTP (UniProtKB | ChEBI)
Active site63Proton donor
Binding site191IMP (UniProtKB | ChEBI)
Active site202
Binding site205IMP (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site284IMP (UniProtKB | ChEBI)
Binding site299IMP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionadenylosuccinate synthase activity
Molecular FunctionGTP binding
Molecular Functionmagnesium ion binding
Biological Process'de novo' AMP biosynthetic process
Biological ProcessIMP metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Adenylosuccinate synthetase
  • EC number
  • Short names
    AMPSase
    ; AdSS
  • Alternative names
    • IMP--aspartate ligase

Gene names

    • ORF names
      UY3_05308

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Testudinata > Testudines > Cryptodira > Durocryptodira > Americhelydia > Chelonioidea > Cheloniidae > Chelonia

Accessions

  • Primary accession
    M7BP59

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the adenylosuccinate synthetase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    420
  • Mass (Da)
    46,174
  • Last updated
    2013-05-29 v1
  • Checksum
    B1802E6AFD7DA6BA
MSENGASAPPVPNGECAARPPGNKVTVVLGAQWGDEGKGKLVDLLAQDADIVCRCQGGNNAGHTVVVDSVEYDFHLLPSGIINPKVIAFIGKYGIFQNCNFNTNTSPDSWSSILEAINIHYSSEHRNGVVIHLPGLFEEAEKNVKKGKGLEGWEKRLIISDRAHIVKISSLSSHLESNMYDFYFFESLGTTKKGIGPVYSSKAARSGLRMCDLVSDFGEFSERFKVLANQYKAIYPTLEIDLEGELKKLKGYIERIKPMVRDGVYFIHEALHGPPKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRANQEVLNKVEVQYETFPGWNTDISNARTFDELPVNAQNYVRFIELELGIPVKWIGVGKSRESMIQIF

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KB522027
EMBL· GenBank· DDBJ
EMP37495.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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