M7BL82 · M7BL82_CHEMY

Function

function

The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.
Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoskeleton
Cellular Componentdystroglycan complex
Cellular Componentextracellular region
Cellular Componentnucleoplasm
Cellular Componentpostsynaptic membrane
Cellular Componentsarcolemma
Molecular Functioncalcium ion binding
Molecular Functionlaminin binding
Biological Processaxon guidance
Biological Processmorphogenesis of an epithelium
Biological Processmuscle attachment
Biological Processnerve development

Names & Taxonomy

Protein names

  • Recommended name
    Dystroglycan 1
  • Alternative names
    • Dystroglycan
    • Dystrophin-associated glycoprotein 1

Gene names

    • ORF names
      UY3_10050

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Testudinata > Testudines > Cryptodira > Durocryptodira > Americhelydia > Chelonioidea > Cheloniidae > Chelonia

Accessions

  • Primary accession
    M7BL82

Proteomes

Subcellular Location

Cell membrane, sarcolemma
Cell membrane
; Single-pass type I membrane protein
Cytoplasm, cytoskeleton
Nucleus, nucleoplasm
Postsynaptic cell membrane
Secreted, extracellular space

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane980-1001Helical

Keywords

PTM/Processing

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain832-947Peptidase S72

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,115
  • Mass (Da)
    124,700
  • Last updated
    2013-05-29 v1
  • Checksum
    430FF9FCCDA08E02
MGKVFYYPVPPFAFQGKITQYKITLANGADLPKWLEFNPHTSTLQGLPMNEENGEYHLNIAAQEDGCVQKTPRANVNFTLHVQDSILIPEKKTGLSHMPKGNIFSSERCRRDSSLTSAEIIIQAAAESLDVQQRLFLVCTMAEYLHLDPTSLALNPYQGSIHRSRRNLTILAEDIRHISFMESHYTGLYWPVGCGVFAMLYELIQVLRHNVDSHHLSQLLGYEIAGWRIIKREGFERKRSGRQRRQLMVTPTPTLKMTETTAKPTGEDVFTTLPPNSLVYLHRKTAVSPVQSWFSFHKASTAVTSYTDLIPLLVTSQGSLGALEMDPSQNFQSKRPMSSTIFQDLSAFAFPELSPSLIITATALSTEFKGLQNTVSSMPLLLEQPQSHMQELDAFLQSGKSEPSRHHFPSVLSFDIAEPTGKGQFSRPIYTLVTETHYEWPLISPEVSLVKTAPQTHFPEEILMTSVYSCQEDSISGYAHFPEFGIPSSATISPEKLPSTFISTSVQLTTLFGFIPPTDDMFLVLSGGSHLSQELFNGYEYMSNSFMTIPQTDRFPFSEGKTSVPSIIHMDTLIWDRESNSSHVTSILGSSILSSTFPSDAGTSHETGLTAQSYPSNAPLLTLPTDFAGFDSSELSRPTKMFTSYDSSKLRTQNHFPSVLPSGTKDLNSDKSLGTRMPLPTVTMFTLELTEMSNIPSYTAEISARTIFNATSHLYNNAQGQTNTFPKVVNSIKFITATIGCKFHFSVPADTFYDQEDGNSTQLTLGINPVDGSPSGPESWLQFNASHQAMYGYPLSTDFQYSPQEFVLSATDSGGLTVWEPLIIELLKPTSIPCHIYTIRTKNSYCSFLRQRERVGLFLDKLSKYLNSSSLKSITLTALRPGSTVISWYNRSLCTSTNRSLSWCSRDEIQEVLNKLRVPDGNVSPHFAEAMLPEYKIDIVEKVSYGGICLPTTKPFNGSLTLNSTFPTYNEESNSRIRNILLISLCATIMVALILVAHRCYKYHKKILESRSMTFQGRASFDYIDLEMDMLKPRKVPVLQREVPPALHLWIPVPPSSQEQPCRPNVTSVASRLPQSLPPFQPPKYQLPPHYKVDITSCSDQGNIHRRDYPKSGLY

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KB538686
EMBL· GenBank· DDBJ
EMP32778.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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