M7BJC8 · M7BJC8_CHEMY
- ProteinGlutathione hydrolase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids661 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.
Catalytic activity
- an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate
Pathway
Sulfur metabolism; glutathione metabolism.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 199 | L-glutamate (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Active site | 474 | Nucleophile | ||||
Sequence: T | ||||||
Binding site | 492-494 | L-glutamate (UniProtKB | ChEBI) | ||||
Sequence: TIN | ||||||
Binding site | 516 | L-glutamate (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 544-545 | L-glutamate (UniProtKB | ChEBI) | ||||
Sequence: SS | ||||||
Binding site | 567 | L-glutamate (UniProtKB | ChEBI) | ||||
Sequence: G |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | acyltransferase activity | |
Molecular Function | glutathione hydrolase activity | |
Biological Process | glutathione catabolic process | |
Biological Process | peptide modification | |
Biological Process | regulation of immune system process | |
Biological Process | regulation of inflammatory response |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGlutathione hydrolase
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Testudinata > Testudines > Cryptodira > Durocryptodira > Americhelydia > Chelonioidea > Cheloniidae > Chelonia
Accessions
- Primary accessionM7BJC8
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Single-pass type II membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 94-117 | Helical | ||||
Sequence: YLIVGILIGFLVGLVLFLGFFFGL |
Keywords
- Cellular component
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length661
- Mass (Da)72,217
- Last updated2013-05-29 v1
- Checksum7581BC9AF68D468B
Keywords
- Technical term