M7BJC8 · M7BJC8_CHEMY

Function

function

Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.

Catalytic activity

Pathway

Sulfur metabolism; glutathione metabolism.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site199L-glutamate (UniProtKB | ChEBI)
Active site474Nucleophile
Binding site492-494L-glutamate (UniProtKB | ChEBI)
Binding site516L-glutamate (UniProtKB | ChEBI)
Binding site544-545L-glutamate (UniProtKB | ChEBI)
Binding site567L-glutamate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionacyltransferase activity
Molecular Functionglutathione hydrolase activity
Biological Processglutathione catabolic process
Biological Processpeptide modification
Biological Processregulation of immune system process
Biological Processregulation of inflammatory response

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Glutathione hydrolase
  • EC number
  • Alternative names
    • Gamma-glutamyltransferase
    • Gamma-glutamyltranspeptidase

Gene names

    • ORF names
      UY3_10723

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Testudinata > Testudines > Cryptodira > Durocryptodira > Americhelydia > Chelonioidea > Cheloniidae > Chelonia

Accessions

  • Primary accession
    M7BJC8

Proteomes

Subcellular Location

Membrane
; Single-pass type II membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane94-117Helical

Keywords

  • Cellular component

Interaction

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the gamma-glutamyltransferase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    661
  • Mass (Da)
    72,217
  • Last updated
    2013-05-29 v1
  • Checksum
    7581BC9AF68D468B
MLDELKWVNAIRTTLKTKKSYRQRLVINVLRAMQPAFWHRGGFASLQSPSLLVLRVARSEHHEAYSQPLLLFPGPPLLQLGVERGDKRKMKKRYLIVGILIGFLVGLVLFLGFFFGLRSAPQPPAQDGHLYKKAAVATDAGPCSIIGRDILQQGGSAVDAAIAALLCVGLMNPHSMGIGGGLFLTIYTSTGKVEVINAREVAPKNASLDMFGNNTELSLKGGLSIAVPGEIRGYEMAHKRHGRLPWNSLFLPNIKLAREGFPIGKALAKVIKSKEKAIESNPSLCEVFCRGGTILHEGDVIKMPKLANTYETLANEGADAFYTGSLAQQIVKDIREAGGIISMEDLRDYTPILSENPLNITIGEFTMYTPSAPVSGPVLALILNILKGFNFSSDSITTMEKKGLTYHRIVEAFRFAYAKRTLLGDPAFVNITEVIRNMTSEFFADNLRGKINDNATHTVDYYEPEYYTPDNAGTSHLSVVADDGSAVSATSTINQYFGSEVRSNVTGIIFNDEMDDFSSPYIINGFGVPPSTANFIEPGKRPLSSMCPSILVDKTNKIKMVVGASGGTKITTATALTIIKSLWFGYDMMKAVEEPRVHDQLFPNVTELEQNVEQGIEVELEKRKHDIKRTNSSAVVQAILQTADGWAAVSDSRKGGFPAGY

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KB542019
EMBL· GenBank· DDBJ
EMP32153.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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