M7B6Q0 · M7B6Q0_CHEMY

Function

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site65-69NAD+ (UniProtKB | ChEBI)
Binding site75-77NAD+ (UniProtKB | ChEBI)
Binding site147-150NAD+ (UniProtKB | ChEBI)
Active site167Proton acceptor
Binding site175Zn2+ (UniProtKB | ChEBI)
Binding site180Zn2+ (UniProtKB | ChEBI)
Binding site201Zn2+ (UniProtKB | ChEBI)
Binding site204Zn2+ (UniProtKB | ChEBI)
Binding site287-288NAD+ (UniProtKB | ChEBI)
Binding site311-313NAD+ (UniProtKB | ChEBI)
Binding site366NAD+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentnucleus
Molecular Functionmetal ion binding
Molecular FunctionNAD+ binding
Molecular FunctionNAD-dependent histone deacetylase activity
Molecular Functiontransferase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NAD-dependent protein deacetylase sirtuin-2
  • EC number
  • Alternative names
    • NAD-dependent protein defatty-acylase sirtuin-2
    • Regulatory protein SIR2 homolog 2
    • SIR2-like protein 2

Gene names

    • ORF names
      UY3_15080

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Testudinata > Testudines > Cryptodira > Durocryptodira > Americhelydia > Chelonioidea > Cheloniidae > Chelonia

Accessions

  • Primary accession
    M7B6Q0

Proteomes

Subcellular Location

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain37-380Deacetylase sirtuin-type
Region393-441Disordered

Sequence similarities

Belongs to the sirtuin family. Class I subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    441
  • Mass (Da)
    47,909
  • Last updated
    2013-05-29 v1
  • Checksum
    83688C3D8D4CBDAF
MSGATVRSPGSPPGMPVDFLRNLLSRTLGLGSEKPEKVLDELTLDGVSRFMQSEKCRNVVCIVGAGISTSAGIPDFRSPGTGLYANLQSYNLPYPEAIFEINYFKQHPEPFFALARELYPGQFKPTVCHYFIRLLKEKGLLLRCYTQNIDTLERVAGLDQEDLVEAHGTFFTSHCLGSSCKKKYTLDWMKEKIFSTVTPKCDKCQSLVKPDIVFFGENLPPRFFTLMQSDFQKVDLLIIMGTSLQVQPFASLVSRVAAGSTALTPCPPTVCSLQDFQKVDLLIIMGTSLQVQPFASLVSRVPTNTPRLLINKEKTGQVRPFSVPGSCGDGLLERSDPFMSLMGLSTGMDFDSEKAYRQDVAWLGECDQGCTALAELLGWKNELEALVKKEHSAIDAKSGQAGEAGASPSLPPAGATASPSSPPAKPGSSPEKESDAGNKAE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KB566783
EMBL· GenBank· DDBJ
EMP27833.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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