M7B6Q0 · M7B6Q0_CHEMY
- ProteinNAD-dependent protein deacetylase sirtuin-2
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids441 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- N6-hexadecanoyl-L-lysyl-[protein] + NAD+ + H2O = 2''-O-hexadecanoyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]This reaction proceeds in the forward direction.
- N6-tetradecanoyl-L-lysyl-[protein] + NAD+ + H2O = 2''-O-tetradecanoyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]This reaction proceeds in the forward direction.
Cofactor
Note: Binds 1 zinc ion per subunit.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 65-69 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: AGIST | ||||||
Binding site | 75-77 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: DFR | ||||||
Binding site | 147-150 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: QNID | ||||||
Active site | 167 | Proton acceptor | ||||
Sequence: H | ||||||
Binding site | 175 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 180 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 201 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 204 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 287-288 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: TS | ||||||
Binding site | 311-313 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: NKE | ||||||
Binding site | 366 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: C |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | metal ion binding | |
Molecular Function | NAD+ binding | |
Molecular Function | NAD-dependent histone deacetylase activity | |
Molecular Function | transferase activity |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNAD-dependent protein deacetylase sirtuin-2
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Testudinata > Testudines > Cryptodira > Durocryptodira > Americhelydia > Chelonioidea > Cheloniidae > Chelonia
Accessions
- Primary accessionM7B6Q0
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 37-380 | Deacetylase sirtuin-type | ||||
Sequence: KVLDELTLDGVSRFMQSEKCRNVVCIVGAGISTSAGIPDFRSPGTGLYANLQSYNLPYPEAIFEINYFKQHPEPFFALARELYPGQFKPTVCHYFIRLLKEKGLLLRCYTQNIDTLERVAGLDQEDLVEAHGTFFTSHCLGSSCKKKYTLDWMKEKIFSTVTPKCDKCQSLVKPDIVFFGENLPPRFFTLMQSDFQKVDLLIIMGTSLQVQPFASLVSRVAAGSTALTPCPPTVCSLQDFQKVDLLIIMGTSLQVQPFASLVSRVPTNTPRLLINKEKTGQVRPFSVPGSCGDGLLERSDPFMSLMGLSTGMDFDSEKAYRQDVAWLGECDQGCTALAELLGWK | ||||||
Region | 393-441 | Disordered | ||||
Sequence: AIDAKSGQAGEAGASPSLPPAGATASPSSPPAKPGSSPEKESDAGNKAE |
Sequence similarities
Belongs to the sirtuin family. Class I subfamily.
Family and domain databases
Sequence
- Sequence statusComplete
- Length441
- Mass (Da)47,909
- Last updated2013-05-29 v1
- Checksum83688C3D8D4CBDAF
Keywords
- Technical term