M7ANH5 · M7ANH5_CHEMY
- Protein1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1197 (go to sequence)
- Protein existencePredicted
- Annotation score3/5
Function
Catalytic activity
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H+This reaction proceeds in the forward direction.
Cofactor
Note: Binds 1 Ca2+ ion per subunit.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 325 | ||||
Binding site | 326 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 355 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 357 | Ca2+ (UniProtKB | ChEBI) | |||
Active site | 372 | ||||
Binding site | 406 | Ca2+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | calcium ion binding | |
Molecular Function | phosphatidylinositol phospholipase C activity | |
Biological Process | lipid catabolic process | |
Biological Process | phosphatidylinositol-mediated signaling | |
Biological Process | release of sequestered calcium ion into cytosol |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Testudinata > Testudines > Cryptodira > Durocryptodira > Americhelydia > Chelonioidea > Cheloniidae > Chelonia
Accessions
- Primary accessionM7ANH5
Proteomes
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain, coiled coil.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 460-483 | Basic and acidic residues | |||
Region | 460-491 | Disordered | |||
Compositional bias | 497-511 | Acidic residues | |||
Region | 497-516 | Disordered | |||
Domain | 537-653 | PI-PLC Y-box | |||
Domain | 647-772 | C2 | |||
Coiled coil | 880-907 | ||||
Coiled coil | 1063-1127 | ||||
Region | 1145-1169 | Disordered | |||
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,197
- Mass (Da)137,129
- Last updated2013-05-29 v1
- Checksum33E299BA4930FFB2
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 460-483 | Basic and acidic residues | |||
Compositional bias | 497-511 | Acidic residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KB576442 EMBL· GenBank· DDBJ | EMP26786.1 EMBL· GenBank· DDBJ | Genomic DNA |