M7AN60 · M7AN60_CHEMY
- ProteinPhosphoinositide phospholipase C
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids2490 (go to sequence)
- Protein existencePredicted
- Annotation score2/5
Function
Catalytic activity
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H+This reaction proceeds in the forward direction.
Cofactor
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Molecular Function | calcium ion binding | |
Molecular Function | ligand-gated monoatomic ion channel activity | |
Molecular Function | phosphatidylinositol phospholipase C activity | |
Biological Process | lipid catabolic process | |
Biological Process | phosphatidylinositol-mediated signaling | |
Biological Process | release of sequestered calcium ion into cytosol |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphoinositide phospholipase C
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Testudinata > Testudines > Cryptodira > Durocryptodira > Americhelydia > Chelonioidea > Cheloniidae > Chelonia
Accessions
- Primary accessionM7AN60
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 1929-1950 | Helical | |||
Transmembrane | 1962-1984 | Helical | |||
Transmembrane | 2141-2164 | Helical | |||
Transmembrane | 2252-2270 | Helical | |||
Transmembrane | 2425-2448 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 1-110 | PH | |||
Domain | 135-164 | EF-hand | |||
Domain | 165-201 | EF-hand | |||
Region | 437-466 | Disordered | |||
Compositional bias | 441-456 | Acidic residues | |||
Region | 495-565 | Disordered | |||
Compositional bias | 513-533 | Basic and acidic residues | |||
Domain | 597-710 | PI-PLC Y-box | |||
Domain | 711-840 | C2 | |||
Region | 879-1009 | Disordered | |||
Compositional bias | 926-945 | Basic and acidic residues | |||
Compositional bias | 981-998 | Polar residues | |||
Region | 1082-1140 | Disordered | |||
Compositional bias | 1087-1117 | Polar residues | |||
Region | 1156-1181 | Disordered | |||
Region | 1247-1343 | Disordered | |||
Compositional bias | 1249-1279 | Polar residues | |||
Compositional bias | 1302-1318 | Polar residues | |||
Compositional bias | 1320-1337 | Basic and acidic residues | |||
Region | 1389-1411 | Disordered | |||
Region | 1484-1503 | Disordered | |||
Region | 1535-1560 | Disordered | |||
Compositional bias | 1539-1560 | Polar residues | |||
Region | 1604-1624 | Disordered | |||
Region | 1648-1710 | Disordered | |||
Compositional bias | 1660-1693 | Polar residues | |||
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length2,490
- Mass (Da)275,824
- Last updated2013-05-29 v1
- MD5 ChecksumE393EBB806C4E23FF02B9AAE8D0B3CD8
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 441-456 | Acidic residues | |||
Compositional bias | 513-533 | Basic and acidic residues | |||
Compositional bias | 926-945 | Basic and acidic residues | |||
Compositional bias | 981-998 | Polar residues | |||
Compositional bias | 1087-1117 | Polar residues | |||
Compositional bias | 1249-1279 | Polar residues | |||
Compositional bias | 1302-1318 | Polar residues | |||
Compositional bias | 1320-1337 | Basic and acidic residues | |||
Compositional bias | 1539-1560 | Polar residues | |||
Compositional bias | 1660-1693 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KB585326 EMBL· GenBank· DDBJ | EMP25954.1 EMBL· GenBank· DDBJ | Genomic DNA |