M6G211 · M6G211_LEPIR
- ProteinPolyamine aminopropyltransferase
- GenespeE
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids280 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
Catalytic activity
- S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H+
Pathway
Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 33 | S-methyl-5'-thioadenosine (UniProtKB | ChEBI) | |||
Binding site | 64 | spermidine (UniProtKB | ChEBI) | |||
Binding site | 88 | spermidine (UniProtKB | ChEBI) | |||
Binding site | 108 | S-methyl-5'-thioadenosine (UniProtKB | ChEBI) | |||
Binding site | 139-140 | S-methyl-5'-thioadenosine (UniProtKB | ChEBI) | |||
Active site | 157 | Proton acceptor | |||
Binding site | 157-160 | spermidine (UniProtKB | ChEBI) | |||
Binding site | 164 | S-methyl-5'-thioadenosine (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | spermidine synthase activity | |
Biological Process | spermidine biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePolyamine aminopropyltransferase
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Spirochaetota > Spirochaetia > Leptospirales > Leptospiraceae > Leptospira
Accessions
- Primary accessionM6G211
Proteomes
Interaction
Subunit
Homodimer or homotetramer.
Structure
Sequence
- Sequence statusComplete
- Length280
- Mass (Da)31,957
- Last updated2013-05-29 v1
- Checksum1F67AA1877498657
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AFLW02000254 EMBL· GenBank· DDBJ | EMM79033.1 EMBL· GenBank· DDBJ | Genomic DNA |