M5E173 · M5E173_9FIRM
- ProteinShikimate kinase
- GenearoK
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids533 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
Catalytic activity
- 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 Mg2+ ion per subunit.
Pathway
Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.
Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 10-15 | ATP (UniProtKB | ChEBI) | |||
Binding site | 14 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 32 | substrate | |||
Binding site | 56 | substrate | |||
Binding site | 79 | substrate | |||
Binding site | 118 | ATP (UniProtKB | ChEBI) | |||
Binding site | 137 | substrate | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | 3-dehydroquinate synthase activity | |
Molecular Function | ATP binding | |
Molecular Function | magnesium ion binding | |
Molecular Function | shikimate kinase activity | |
Biological Process | amino acid biosynthetic process | |
Biological Process | aromatic amino acid family biosynthetic process | |
Biological Process | chorismate biosynthetic process | |
Biological Process | phosphorylation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameShikimate kinase
- EC number
- Short namesSK
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacillota > Clostridia > Halanaerobiales > Halanaerobiaceae > Halanaerobium
Accessions
- Primary accessionM5E173
Proteomes
Subcellular Location
Interaction
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 236-493 | 3-dehydroquinate synthase | |||
Sequence similarities
Belongs to the shikimate kinase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length533
- Mass (Da)60,620
- Last updated2013-05-29 v1
- MD5 Checksum805EF82A5DC9344E5324B3FF67E8407C
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CAUI01000015 EMBL· GenBank· DDBJ | CCU79347.1 EMBL· GenBank· DDBJ | Genomic DNA |