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M5E173 · M5E173_9FIRM

Function

function

Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.
NAD+ (UniProtKB | Rhea| CHEBI:57540 )

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.
Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site10-15ATP (UniProtKB | ChEBI)
Binding site14Mg2+ (UniProtKB | ChEBI)
Binding site32substrate
Binding site56substrate
Binding site79substrate
Binding site118ATP (UniProtKB | ChEBI)
Binding site137substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function3-dehydroquinate synthase activity
Molecular FunctionATP binding
Molecular Functionmagnesium ion binding
Molecular Functionshikimate kinase activity
Biological Processamino acid biosynthetic process
Biological Processaromatic amino acid family biosynthetic process
Biological Processchorismate biosynthetic process
Biological Processphosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Shikimate kinase
  • EC number
  • Short names
    SK

Gene names

    • Name
      aroK
    • ORF names
      HSACCH_01257

Organism names

Accessions

  • Primary accession
    M5E173

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain236-4933-dehydroquinate synthase

Sequence similarities

Belongs to the shikimate kinase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    533
  • Mass (Da)
    60,620
  • Last updated
    2013-05-29 v1
  • MD5 Checksum
    805EF82A5DC9344E5324B3FF67E8407C
MKIVLTGFMAAGKTTVGKKIAAYKNFNFYDSDDLITEREEMSIKEIFEIKGEKYFREVEKRVITELLNSKEDLVLAPGGGAVLNQELREMMINKAEVFCLDISAEEVLKRNSESKIVRPLLEVDKPLDMVRSLLEERNQYYAEIPFHIDSEKYSAEAIADIIIAELPDQKLNIEIKNKDQAYPVIIDQEYKQNSFESVISKVRNRKVLLLADKKVIAEHSEPVIKKLKNAADVIEFNLEAGEKIKDLSVLEKIYTLLYENSFSRSDYLIAFGGGTIGDLGALAASTFLRGIKLIQMPTTLISQLDSSVGGKTAVNFRETKNLIGSFYQAEIVYYQLEWLKTLEKAELKSGLGEVIKYAILGGNPLFNILKENKDKILELDKDLMLEISKISLQMKDYYVSQDVKDQGQRKKLNLGHSFGHAVEGAEKFRYKHGEAVVMGIAFTAFLSNKIGSLSDQSFKEIIELINIYDYQLFPSAAVGAEKLASYIAHDKKIADNKMWWVLINDIGDTYLSDKFDHNNIQKHMEEYLCKKWL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CAUI01000015
EMBL· GenBank· DDBJ
CCU79347.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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