M4ZRS0 · M4ZRS0_9ACTN
- Proteinproline dehydrogenase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids308 (go to sequence)
- Protein existencePredicted
- Annotation score2/5
Function
Catalytic activity
- a quinone + L-proline = (S)-1-pyrroline-5-carboxylate + a quinol + H+
Cofactor
Note: Binds 1 FAD per subunit.
Pathway
Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 98 | substrate | ||||
Sequence: K | ||||||
Binding site | 136 | FAD (UniProtKB | ChEBI) | ||||
Sequence: M | ||||||
Binding site | 164 | FAD (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 188-190 | FAD (UniProtKB | ChEBI) | ||||
Sequence: KGA | ||||||
Binding site | 202 | FAD (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 227-228 | FAD (UniProtKB | ChEBI) | ||||
Sequence: TH | ||||||
Binding site | 289 | substrate | ||||
Sequence: R | ||||||
Binding site | 290 | substrate | ||||
Sequence: R |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | nucleotide binding | |
Molecular Function | proline dehydrogenase activity | |
Biological Process | proline catabolic process to glutamate |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameproline dehydrogenase
- EC number
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Streptosporangiales > Streptosporangiaceae > Streptosporangium
Accessions
- Primary accessionM4ZRS0
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 42-300 | Proline dehydrogenase | ||||
Sequence: VEAIRHLAAAGLAVSVDHLGEETKDAAAAAQTARAYATLLSPLGELGLGDRAEVSVKLSAVGQALGADGDKIALENARQICEAARACGANVTLDMEDHTTVDSTLETLRALREDFPSVGVAVQSYLFRSEADCRDLAYRGSRVRLVKGAYAEPASVAHQHKTEVDRAYVRCLRVLMSGAGYPMVATHDDRLISITETLADRFGRSPGDYEYQMLYGIRTDRQQALAGAGHVMRVYIPYGDDWYGYFMRRLAERPANIAF |
Family and domain databases
Sequence
- Sequence statusComplete
- Length308
- Mass (Da)33,358
- Last updated2013-05-29 v1
- Checksum18FE36166F478676