M4YPU2 · M4YPU2_THEXX

Function

function

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

a divalent metal cation (UniProtKB | Rhea| CHEBI:60240 )

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site64Mg2+ 1 (UniProtKB | ChEBI); catalytic
Binding site80Mg2+ 1 (UniProtKB | ChEBI); catalytic
Binding site82Mg2+ 1 (UniProtKB | ChEBI); catalytic
Binding site83Mg2+ 1 (UniProtKB | ChEBI); catalytic
Binding site208Mg2+ 1 (UniProtKB | ChEBI); catalytic
Active site326Proton acceptor
Binding site326-327NAD+ (UniProtKB | ChEBI)
Binding site331NAD+ (UniProtKB | ChEBI)
Binding site393-394NAD+ (UniProtKB | ChEBI)
Binding site404NAD+ (UniProtKB | ChEBI)
Binding site421NAD+ (UniProtKB | ChEBI)
Binding site423NAD+ (UniProtKB | ChEBI)
Binding site434-439NAD+ (UniProtKB | ChEBI)
Binding site458NAD+ (UniProtKB | ChEBI)
Binding site492NAD+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionhydrolase activity
Molecular Functionmetal ion binding
Molecular FunctionNAD+ kinase activity
Biological ProcessNAD metabolic process
Biological ProcessNADP biosynthetic process
Biological Processphosphatidylinositol phosphate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NAD kinase
  • EC number
  • Alternative names
    • ATP-dependent NAD kinase

Gene names

    • Name
      nadK
    • ORF names
      TALC_01451

Organism names

Accessions

  • Primary accession
    M4YPU2

Proteomes

Subcellular Location

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the NAD kinase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    533
  • Mass (Da)
    57,633
  • Last updated
    2013-05-29 v1
  • Checksum
    975361CC47D43412
MDTLAQIADAVVKAVGLIPTLEERGKDIEMGADGTPTSEIDKVAENTVLDFIVRNRVPLNVLSEEIGFVDYGYDETLVLDPIDGTSNAIAGVPLFTVSLAVGNKDLDGIHTAYLRNIATGESMWAEKGRGAFKDGRRISVRSPDFKHLFVMIYMGNGADPKSFELAKNVKSSRSYGCASLEMALVAEGQCDAYYMNSERYNRGIRIVDIAASYLILREAGGHVYDLSGKAFNMPFDLSARSNFVACAEPSVFDFIMGKNPKHVGKTVYGLVANPNVPDLENYVRRVADALGQETLVCDATSGEILGREGTDVRDMDVDVVITIGGDGTILRAAMGTRAPIMGINAGGVGFLAEITPDRIEEGIARLRSGDFTISERFKLDSFLNGKKMEPTINEAVVHTDSVAKIRQFKVYVDGKLATEVRADGIIISTPTGSTSYAMSLGAPMVDPGVDALLIVPMAAYKFASRPFVVPSGVKVTVECVRDKGCLLVLDGQAEHPIEGGSKLDFVRSSERVRFVSFGADFYSRVREKLVNTI

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP002916
EMBL· GenBank· DDBJ
AGI48427.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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