M4YPU2 · M4YPU2_THEXX
- ProteinNAD kinase
- GenenadK
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids533 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
Catalytic activity
- ATP + NAD+ = ADP + H+ + NADP+
Cofactor
Protein has several cofactor binding sites:
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 64 | Mg2+ 1 (UniProtKB | ChEBI); catalytic | ||||
Sequence: E | ||||||
Binding site | 80 | Mg2+ 1 (UniProtKB | ChEBI); catalytic | ||||
Sequence: D | ||||||
Binding site | 82 | Mg2+ 1 (UniProtKB | ChEBI); catalytic | ||||
Sequence: I | ||||||
Binding site | 83 | Mg2+ 1 (UniProtKB | ChEBI); catalytic | ||||
Sequence: D | ||||||
Binding site | 208 | Mg2+ 1 (UniProtKB | ChEBI); catalytic | ||||
Sequence: D | ||||||
Active site | 326 | Proton acceptor | ||||
Sequence: D | ||||||
Binding site | 326-327 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: DG | ||||||
Binding site | 331 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 393-394 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: NE | ||||||
Binding site | 404 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 421 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 423 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 434-439 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: TSYAMS | ||||||
Binding site | 458 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: A | ||||||
Binding site | 492 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: Q |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | hydrolase activity | |
Molecular Function | metal ion binding | |
Molecular Function | NAD+ kinase activity | |
Biological Process | NAD metabolic process | |
Biological Process | NADP biosynthetic process | |
Biological Process | phosphatidylinositol phosphate biosynthetic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNAD kinase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageArchaea > Candidatus Thermoplasmatota > Thermoplasmata > Thermoplasmatales
Accessions
- Primary accessionM4YPU2
Proteomes
Subcellular Location
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length533
- Mass (Da)57,633
- Last updated2013-05-29 v1
- Checksum975361CC47D43412
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP002916 EMBL· GenBank· DDBJ | AGI48427.1 EMBL· GenBank· DDBJ | Genomic DNA |