M3XF85 · M3XF85_FELCA
- ProteinVery-long-chain 3-oxoacyl-CoA reductase
- GeneHSD17B12
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids312 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation.
Catalytic activity
- (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + NADPH + H+ = (3R)-hydroxy-(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + NADP+
- (7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-CoA + NADPH + H+ = (3R)-hydroxy-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + NADP+
- (8Z,11Z,14Z)-3-oxoeicosatrienoyl-CoA + NADPH + H+ = (3R)-hydroxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA + NADP+
- 3-oxooctadecanoyl-CoA + NADPH + H+ = (3R)-hydroxyoctadecanoyl-CoA + NADP+
Pathway
Lipid metabolism; fatty acid biosynthesis.
Steroid biosynthesis; estrogen biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | |
Biological Process | steroid biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameVery-long-chain 3-oxoacyl-CoA reductase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Feliformia > Felidae > Felinae > Felis
Accessions
- Primary accessionM3XF85
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 12-34 | Helical | |||
Transmembrane | 183-204 | Helical | |||
Transmembrane | 272-291 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Proteomic databases
Expression
Gene expression databases
Structure
Sequence
- Sequence statusComplete
- Length312
- Mass (Da)34,215
- Last updated2013-05-01 v1
- Checksum7DF982DD3B498EA6
Computationally mapped potential isoform sequences
There are 6 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A337SLI0 | A0A337SLI0_FELCA | HSD17B12 | 276 | ||
A0A5F5Y1G6 | A0A5F5Y1G6_FELCA | HSD17B12 | 361 | ||
A0A5F5Y6Z8 | A0A5F5Y6Z8_FELCA | HSD17B12 | 269 | ||
M3WWB8 | M3WWB8_FELCA | HSD17B12 | 286 | ||
A0A337SAN8 | A0A337SAN8_FELCA | HSD17B12 | 98 | ||
A0A5F5XIW7 | A0A5F5XIW7_FELCA | HSD17B12 | 291 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AANG04004363 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |