M3XF85 · M3XF85_FELCA

Function

function

Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation.

Catalytic activity

Pathway

Lipid metabolism; fatty acid biosynthesis.
Steroid biosynthesis; estrogen biosynthesis.

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Biological Processsteroid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Very-long-chain 3-oxoacyl-CoA reductase
  • EC number
  • Alternative names
    • 17-beta-hydroxysteroid dehydrogenase 12
    • 3-ketoacyl-CoA reductase
    • Estradiol 17-beta-dehydrogenase 12

Gene names

    • Name
      HSD17B12
    • Synonyms
      ALKBH3

Organism names

  • Taxonomic identifier
  • Strain
    • Abyssinian
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Feliformia > Felidae > Felinae > Felis

Accessions

  • Primary accession
    M3XF85

Proteomes

Organism-specific databases

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane12-34Helical
Transmembrane183-204Helical
Transmembrane272-291Helical

Keywords

PTM/Processing

Proteomic databases

Expression

Gene expression databases

Family & Domains

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    312
  • Mass (Da)
    34,215
  • Last updated
    2013-05-01 v1
  • Checksum
    7DF982DD3B498EA6
MESALPAAGFLYWVGAGTVAYLALRISCSLFTALRVWGLSHEVGVGPGLGEWAVVTGSTDGIGKSYAEELAKHGMKIVLISRSQDKLNQVSSEIREKFKVETMTIAVDFASEDIYDKIKTSLAGLKIGVLVNNVGVSYEYPEYFLDVPDLDNTIKKLINVNVLSVCKMTRLVLPGMVERSKGAILNISSASGLVPVPLLAMYSATKAFVDFFSQCLHEEYRSKGIFVQSVLPFFIATKLSKIRKPTLDTPSAETFVKSAIKTVGLQSRTTGYLIHSLMGSIISVMPTWLYFKITTNMGKSTRARYLKKAKKN

Computationally mapped potential isoform sequences

There are 6 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A337SLI0A0A337SLI0_FELCAHSD17B12276
A0A5F5Y1G6A0A5F5Y1G6_FELCAHSD17B12361
A0A5F5Y6Z8A0A5F5Y6Z8_FELCAHSD17B12269
M3WWB8M3WWB8_FELCAHSD17B12286
A0A337SAN8A0A337SAN8_FELCAHSD17B1298
A0A5F5XIW7A0A5F5XIW7_FELCAHSD17B12291

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AANG04004363
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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