M3X3T9 · M3X3T9_FELCA
- ProteinPlasminogen
- GenePLG
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids806 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
function
Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells.
Catalytic activity
Activity regulation
Converted into plasmin by plasminogen activators, both plasminogen and its activator being bound to fibrin.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 158 | L-lysine (UniProtKB | ChEBI) | |||
Binding site | 172 | L-lysine (UniProtKB | ChEBI) | |||
Binding site | 428 | L-lysine (UniProtKB | ChEBI) | |||
Binding site | 441 | L-lysine (UniProtKB | ChEBI) | |||
Active site | 618 | Charge relay system | |||
Active site | 661 | Charge relay system | |||
Active site | 756 | Charge relay system | |||
GO annotations
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePlasminogen
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Feliformia > Felidae > Felinae > Felis
Accessions
- Primary accessionM3X3T9
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-19 | ||||
Chain | PRO_5016258091 | 20-806 | Plasminogen | ||
Disulfide bond | 185↔262 | ||||
Disulfide bond | 206↔245 | ||||
Disulfide bond | 234↔257 | ||||
Disulfide bond | 271↔348 | ||||
Disulfide bond | 292↔331 | ||||
Disulfide bond | 320↔343 | ||||
Disulfide bond | 373↔450 | ||||
Disulfide bond | 394↔433 | ||||
Disulfide bond | 422↔445 | ||||
Keywords
- PTM
Proteomic databases
Expression
Gene expression databases
Interaction
Subunit
Interacts with CSPG4 and AMOT. Interacts (via the Kringle domains) with HRG; the interaction tethers PLG to the cell surface and enhances its activation. Interacts (via Kringle 4 domain) with ADA; the interaction stimulates PLG activation when in complex with DPP4. Angiostatin: Interacts with ATP5F1A; the interaction inhibits most of the angiogenic effects of angiostatin.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 20-98 | Apple | |||
Domain | 102-181 | Kringle | |||
Domain | 184-262 | Kringle | |||
Domain | 270-348 | Kringle | |||
Domain | 372-450 | Kringle | |||
Region | 454-477 | Disordered | |||
Compositional bias | 457-471 | Polar residues | |||
Domain | 476-556 | Kringle | |||
Domain | 577-804 | Peptidase S1 | |||
Sequence similarities
Belongs to the peptidase S1 family. Plasminogen subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length806
- Mass (Da)90,360
- Last updated2018-10-10 v3
- MD5 Checksum9A1CB194EDA855A3711F1F9B3F9ED363
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 457-471 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AANG04000169 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |