M3WV10 · M3WV10_FELCA

Function

Catalytic activity

Cofactor

FAD (UniProtKB | Rhea| CHEBI:57692 )

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentnucleus
Molecular Functionidentical protein binding
Molecular FunctionNAD(P)H dehydrogenase (quinone) activity
Molecular FunctionNADH:ubiquinone reductase (non-electrogenic) activity
Biological Processcell redox homeostasis
Biological Processinnate immune response
Biological Processnegative regulation of ferroptosis
Biological Processnegative regulation of protein catabolic process
Biological Processprotein catabolic process
Biological Processprotein polyubiquitination
Biological Processremoval of superoxide radicals
Biological Processresponse to lipopolysaccharide
Biological Processubiquinone metabolic process
Biological Processvitamin E metabolic process
Biological Processvitamin K metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NAD(P)H dehydrogenase [quinone] 1
  • EC number
  • Alternative names
    • Azoreductase
    • DT-diaphorase
    • Menadione reductase
    • NAD(P)H:quinone oxidoreductase 1
    • Phylloquinone reductase
    • Quinone reductase 1

Gene names

    • Name
      NQO1

Organism names

  • Taxonomic identifier
  • Strain
    • Abyssinian
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Feliformia > Felidae > Felinae > Felis

Accessions

  • Primary accession
    M3WV10

Proteomes

Subcellular Location

PTM/Processing

Keywords

Proteomic databases

Expression

Gene expression databases

Interaction

Subunit

Homodimer. Interacts with PDLIM4 isoform 2; this interaction stabilizes PDLIM4 isoform 2 in response to oxidative stress and protects it from ubiquitin-independent degradation by the core 20S proteasome. Interacts with TP73 (via SAM domain); this interaction is NADH-dependent, stabilizes TP73 in response to oxidative stress and protects it from ubiquitin-independent degradation by the 20S proteasome. Interacts with TP53; this interaction is NADH-dependent, stabilizes TP53 in response to oxidative stress and protects it from ubiquitin-independent degradation by the 20S proteasome.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain5-210Flavodoxin-like fold

Sequence similarities

Belongs to the NAD(P)H dehydrogenase (quinone) family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    274
  • Mass (Da)
    30,880
  • Last updated
    2018-10-10 v2
  • Checksum
    96C5F76CCE501A15
LAARRALIVLAHAERTSFNHAMKEAAVEALKRKGWEVTVSDLYAMNFNPVISRRDITGPLKDPENFQYPAESVLAYKEGRLSPDIVAEQKKLEAADLVIFQFPLQWFGVPAILKGWFERVLIGGFAYTYAAMYDNGPFRNKKTVLSITTGGSGSMYSLQGIHGDMNIILWPIQSGTLHFCGFQVLEPQLTYSVGHTPTDARIQILDGWKKRLENIWDETPLYFAPSSLFDLNFQAGFIMKKEVQDEQKNEKFGLSVGHHLGKSIPTDNQIKARK

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A337SPA1A0A337SPA1_FELCANQO1202
A0A337S4K0A0A337S4K0_FELCANQO1236
A0A337SRW6A0A337SRW6_FELCANQO1240

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AANG04002512
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help