M3WV10 · M3WV10_FELCA
- ProteinNAD(P)H dehydrogenase [quinone] 1
- GeneNQO1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids274 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
Catalytic activity
- ubiquinone-10 + NADH + H+ = ubiquinol-10 + NAD+This reaction proceeds in the forward direction.
- menadione + NADH + H+ = menadiol + NAD+This reaction proceeds in the forward direction.
Cofactor
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | nucleus | |
Molecular Function | identical protein binding | |
Molecular Function | NAD(P)H dehydrogenase (quinone) activity | |
Molecular Function | NADH:ubiquinone reductase (non-electrogenic) activity | |
Biological Process | cell redox homeostasis | |
Biological Process | innate immune response | |
Biological Process | negative regulation of ferroptosis | |
Biological Process | negative regulation of protein catabolic process | |
Biological Process | protein catabolic process | |
Biological Process | protein polyubiquitination | |
Biological Process | removal of superoxide radicals | |
Biological Process | response to lipopolysaccharide | |
Biological Process | ubiquinone metabolic process | |
Biological Process | vitamin E metabolic process | |
Biological Process | vitamin K metabolic process |
Keywords
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNAD(P)H dehydrogenase [quinone] 1
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Feliformia > Felidae > Felinae > Felis
Accessions
- Primary accessionM3WV10
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Expression
Gene expression databases
Interaction
Subunit
Homodimer. Interacts with PDLIM4 isoform 2; this interaction stabilizes PDLIM4 isoform 2 in response to oxidative stress and protects it from ubiquitin-independent degradation by the core 20S proteasome. Interacts with TP73 (via SAM domain); this interaction is NADH-dependent, stabilizes TP73 in response to oxidative stress and protects it from ubiquitin-independent degradation by the 20S proteasome. Interacts with TP53; this interaction is NADH-dependent, stabilizes TP53 in response to oxidative stress and protects it from ubiquitin-independent degradation by the 20S proteasome.
Protein-protein interaction databases
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length274
- Mass (Da)30,880
- Last updated2018-10-10 v2
- Checksum96C5F76CCE501A15
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A337SPA1 | A0A337SPA1_FELCA | NQO1 | 202 | ||
A0A337S4K0 | A0A337S4K0_FELCA | NQO1 | 236 | ||
A0A337SRW6 | A0A337SRW6_FELCA | NQO1 | 240 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AANG04002512 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |