M3WLT7 · M3WLT7_FELCA

Function

function

Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin.

Catalytic activity

Cofactor

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Note: Binds 1 Ca2+ ion per subunit.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site52Ca2+ (UniProtKB | ChEBI)
Binding site53Ca2+ (UniProtKB | ChEBI)
Active site88Nucleophile
Binding site88Ca2+ (UniProtKB | ChEBI); via 3-oxoalanine
Binding site317Ca2+ (UniProtKB | ChEBI)
Binding site318Ca2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcell surface
Cellular Componentendoplasmic reticulum
Cellular Componentextracellular space
Cellular ComponentGolgi stack
Molecular Functionarylsulfatase activity
Molecular Functioncalcium ion binding
Molecular FunctionN-acetylglucosamine-6-sulfatase activity
Biological Processbone development
Biological Processchondrocyte development
Biological Processembryonic skeletal system development
Biological Processesophagus smooth muscle contraction
Biological Processglial cell-derived neurotrophic factor receptor signaling pathway
Biological Processheparan sulfate proteoglycan metabolic process
Biological Processinnervation
Biological Processkidney development
Biological Processnegative regulation of fibroblast growth factor receptor signaling pathway
Biological Processpositive regulation of Wnt signaling pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Extracellular sulfatase
  • EC number

Gene names

    • Name
      SULF2

Organism names

  • Taxonomic identifier
  • Strain
    • Abyssinian
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Feliformia > Felidae > Felinae > Felis

Accessions

  • Primary accession
    M3WLT7

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain, modified residue.

TypeIDPosition(s)Description
Signal1-24
ChainPRO_502358604725-869Extracellular sulfatase
Modified residue883-oxoalanine (Cys)

Post-translational modification

The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

Proteomic databases

Expression

Gene expression databases

Family & Domains

Features

Showing features for domain, compositional bias, region, coiled coil.

TypeIDPosition(s)Description
Domain44-374Sulfatase N-terminal
Domain529-663Extracellular sulfatase C-terminal
Compositional bias547-579Basic and acidic residues
Region547-590Disordered
Coiled coil627-654

Sequence similarities

Belongs to the sulfatase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    869
  • Mass (Da)
    100,092
  • Last updated
    2018-10-10 v3
  • Checksum
    CF450A05D1B5C16F
MASPGLLLCLLSAAVFSLLGGSSAFLSHHRLKGRFQRDRRNIRPNIILVLTDDQDVELGSMQVMNKTRRIMERGGAHFVNAFVTTPMCCPSRSSILTGKYVHNHNTYTNNENCSSPSWQAQHESRTFAVYLNSTGYRTAFFGKYLNEYNGSYVPPGWKEWVGLLKNSRFYNYTLCRNGVKEKHGFDYSKDYLTDLITNDSVSFFRTSKKMYPHRPVLMVISHAAPHGPEDSAPQYSGLFPNASQHITPSYNYAPNPDKHWIMRYTGPMKPIHMEFTNMLQRKRLQTLMSVDDSMETIYNMLVETGELDNTYIMYTADHGYHIGQFGLVKGKSMPYEFDIRVPFYVRGPNVEAGSLNPHIVLNIDLAPTILDIAGLDIPSDMDGKSILKLLDTERPVNRFHLKKKVRVWRDSFLVERGKLLHKRDNDKVDAQEENFLPKYQRVKDLCQRAEYQTACEQLGQKWQCVEDASGKLKLHRCKAPARPGGRALSNLVPKYYGQGGDACLCAGSDYKLSLAGRRKKFFKKKYKTGYARNRSIRSVAIEADGGVHHRGLDDAPQSRNLTKRHWSGAPEDPDDKDPGDFSGTGGLPDYSAPNPIKVTHRCYILENDTVQCDLGLYQSLQAWKDHKLHIDHEIETLQNKIKNLREVRGHLKKKRPEECDCHKISYHTQHKGRLKHKGSSLHPFRKGLQEKDKVWLLREQKRKKKLRKLLKRLQNNDTCSMPGLTCFTHDNQHWQTAPLWTLGPFCACTSANNNTYWCMRTINETHNFLFCEFATGFLEYFDLNTDPYQLMNAVNTLDRDVLNQLHVQLMELRSCKGYKQCNPRTRNMDLGLKDGGSYEQYRQFQRRKWPEMKRPSSKSLGQLWEGWEG

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A337RXK1A0A337RXK1_FELCASULF2849
A0A5F5XWT4A0A5F5XWT4_FELCASULF2893

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias547-579Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AANG04003379
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

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