M3WLT7 · M3WLT7_FELCA
- ProteinExtracellular sulfatase
- GeneSULF2
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids869 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
function
Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin.
Catalytic activity
- an aryl sulfate + H2O = a phenol + sulfate + H+
Cofactor
Note: Binds 1 Ca2+ ion per subunit.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 52 | Ca2+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 53 | Ca2+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Active site | 88 | Nucleophile | ||||
Sequence: C | ||||||
Binding site | 88 | Ca2+ (UniProtKB | ChEBI); via 3-oxoalanine | ||||
Sequence: C | ||||||
Binding site | 317 | Ca2+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 318 | Ca2+ (UniProtKB | ChEBI) | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cell surface | |
Cellular Component | endoplasmic reticulum | |
Cellular Component | extracellular space | |
Cellular Component | Golgi stack | |
Molecular Function | arylsulfatase activity | |
Molecular Function | calcium ion binding | |
Molecular Function | N-acetylglucosamine-6-sulfatase activity | |
Biological Process | bone development | |
Biological Process | chondrocyte development | |
Biological Process | embryonic skeletal system development | |
Biological Process | esophagus smooth muscle contraction | |
Biological Process | glial cell-derived neurotrophic factor receptor signaling pathway | |
Biological Process | heparan sulfate proteoglycan metabolic process | |
Biological Process | innervation | |
Biological Process | kidney development | |
Biological Process | negative regulation of fibroblast growth factor receptor signaling pathway | |
Biological Process | positive regulation of Wnt signaling pathway |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameExtracellular sulfatase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Feliformia > Felidae > Felinae > Felis
Accessions
- Primary accessionM3WLT7
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-24 | |||||
Sequence: MASPGLLLCLLSAAVFSLLGGSSA | ||||||
Chain | PRO_5023586047 | 25-869 | Extracellular sulfatase | |||
Sequence: FLSHHRLKGRFQRDRRNIRPNIILVLTDDQDVELGSMQVMNKTRRIMERGGAHFVNAFVTTPMCCPSRSSILTGKYVHNHNTYTNNENCSSPSWQAQHESRTFAVYLNSTGYRTAFFGKYLNEYNGSYVPPGWKEWVGLLKNSRFYNYTLCRNGVKEKHGFDYSKDYLTDLITNDSVSFFRTSKKMYPHRPVLMVISHAAPHGPEDSAPQYSGLFPNASQHITPSYNYAPNPDKHWIMRYTGPMKPIHMEFTNMLQRKRLQTLMSVDDSMETIYNMLVETGELDNTYIMYTADHGYHIGQFGLVKGKSMPYEFDIRVPFYVRGPNVEAGSLNPHIVLNIDLAPTILDIAGLDIPSDMDGKSILKLLDTERPVNRFHLKKKVRVWRDSFLVERGKLLHKRDNDKVDAQEENFLPKYQRVKDLCQRAEYQTACEQLGQKWQCVEDASGKLKLHRCKAPARPGGRALSNLVPKYYGQGGDACLCAGSDYKLSLAGRRKKFFKKKYKTGYARNRSIRSVAIEADGGVHHRGLDDAPQSRNLTKRHWSGAPEDPDDKDPGDFSGTGGLPDYSAPNPIKVTHRCYILENDTVQCDLGLYQSLQAWKDHKLHIDHEIETLQNKIKNLREVRGHLKKKRPEECDCHKISYHTQHKGRLKHKGSSLHPFRKGLQEKDKVWLLREQKRKKKLRKLLKRLQNNDTCSMPGLTCFTHDNQHWQTAPLWTLGPFCACTSANNNTYWCMRTINETHNFLFCEFATGFLEYFDLNTDPYQLMNAVNTLDRDVLNQLHVQLMELRSCKGYKQCNPRTRNMDLGLKDGGSYEQYRQFQRRKWPEMKRPSSKSLGQLWEGWEG | ||||||
Modified residue | 88 | 3-oxoalanine (Cys) | ||||
Sequence: C |
Post-translational modification
The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.
Proteomic databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, compositional bias, region, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 44-374 | Sulfatase N-terminal | ||||
Sequence: PNIILVLTDDQDVELGSMQVMNKTRRIMERGGAHFVNAFVTTPMCCPSRSSILTGKYVHNHNTYTNNENCSSPSWQAQHESRTFAVYLNSTGYRTAFFGKYLNEYNGSYVPPGWKEWVGLLKNSRFYNYTLCRNGVKEKHGFDYSKDYLTDLITNDSVSFFRTSKKMYPHRPVLMVISHAAPHGPEDSAPQYSGLFPNASQHITPSYNYAPNPDKHWIMRYTGPMKPIHMEFTNMLQRKRLQTLMSVDDSMETIYNMLVETGELDNTYIMYTADHGYHIGQFGLVKGKSMPYEFDIRVPFYVRGPNVEAGSLNPHIVLNIDLAPTILDIAG | ||||||
Domain | 529-663 | Extracellular sulfatase C-terminal | ||||
Sequence: GYARNRSIRSVAIEADGGVHHRGLDDAPQSRNLTKRHWSGAPEDPDDKDPGDFSGTGGLPDYSAPNPIKVTHRCYILENDTVQCDLGLYQSLQAWKDHKLHIDHEIETLQNKIKNLREVRGHLKKKRPEECDCHK | ||||||
Compositional bias | 547-579 | Basic and acidic residues | ||||
Sequence: VHHRGLDDAPQSRNLTKRHWSGAPEDPDDKDPG | ||||||
Region | 547-590 | Disordered | ||||
Sequence: VHHRGLDDAPQSRNLTKRHWSGAPEDPDDKDPGDFSGTGGLPDY | ||||||
Coiled coil | 627-654 | |||||
Sequence: KLHIDHEIETLQNKIKNLREVRGHLKKK |
Sequence similarities
Belongs to the sulfatase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length869
- Mass (Da)100,092
- Last updated2018-10-10 v3
- ChecksumCF450A05D1B5C16F
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A337RXK1 | A0A337RXK1_FELCA | SULF2 | 849 | ||
A0A5F5XWT4 | A0A5F5XWT4_FELCA | SULF2 | 893 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 547-579 | Basic and acidic residues | ||||
Sequence: VHHRGLDDAPQSRNLTKRHWSGAPEDPDDKDPG |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AANG04003379 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |