M3WI73 · M3WI73_FELCA

Function

function

Catalyzes the oxidative deamination of primary and some secondary amine such as neurotransmitters, with concomitant reduction of oxygen to hydrogen peroxide and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. Preferentially oxidizes serotonin. Also catalyzes the oxidative deamination of kynuramine to 3-(2-aminophenyl)-3-oxopropanal that can spontaneously condense to 4-hydroxyquinoline.

Catalytic activity

Cofactor

FAD (UniProtKB | Rhea| CHEBI:57692 )

GO annotations

AspectTerm
Cellular Componentmitochondrial outer membrane
Molecular Functionaliphatic amine oxidase activity
Molecular Functionmonoamine oxidase activity
Molecular Functionprimary methylamine oxidase activity
Biological Processcatecholamine metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Amine oxidase
  • EC number

Gene names

    • Name
      MAOA

Organism names

  • Taxonomic identifier
  • Strain
    • Abyssinian
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Feliformia > Felidae > Felinae > Felis

Accessions

  • Primary accession
    M3WI73

Proteomes

Organism-specific databases

Subcellular Location

Mitochondrion outer membrane
; Single-pass type IV membrane protein

Keywords

PTM/Processing

Keywords

Proteomic databases

Expression

Gene expression databases

Interaction

Subunit

Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer.

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region1-47Disordered
Compositional bias29-47Polar residues
Compositional bias65-121Polar residues
Region65-246Disordered
Compositional bias212-246Polar residues
Region339-380Disordered
Compositional bias364-380Polar residues
Region402-441Disordered
Compositional bias424-438Polar residues
Region459-603Disordered
Compositional bias464-565Polar residues
Compositional bias581-603Polar residues
Domain622-1059Amine oxidase

Sequence similarities

Belongs to the flavin monoamine oxidase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,126
  • Mass (Da)
    121,041
  • Last updated
    2019-12-11 v4
  • Checksum
    0A6792938F3BDA31
MSAHNSPASQGGRGGGGAERAPGAEGIAAQSPSQASISGAAASSMSGSNIHAEWRTLTGSLARQAWSRSATDTGYENTSRSSASAQHDFSLSRRTNTDSDTSLWRFDAHSQSHQIPKSATRLSTAERAAPASDPDASSGRGSVPAPAPPSDSTRVSVSESTLAAGRGYPRVSVPGPPITNNSSPESMPGSDPPVTPGFLRVSTPAPPPPSNTLQESAQRLAPPSVQGSFRSSVQGPPTPNSPLVSQHGSLRFPVAGFPRMSVDRSAQLSNSTVELLQGSAPSSVLSIPRGSLQRSVRYSDVSGASVQASAPPSVPGSPRGSLQGSVLYTNIYRAWVQESAPPSGPGSPRGSLQGSVPYPDVSGEWMQETSSPSVPSSPRGLLQRSVPYLDLYRAWVQETASPPVLGSPPGSLQGSVPYPDVSGGWVQETSSPSVPSPPRGLLQRSVPYLDLYRAWVQENASPPVPGSPRGSLQRSVRYSDVSGASVQETAPPSMLGSPRGSQQGKVPSSDSSQASGQGSAQPSVPGSPRGSQQGPVPSSDSSRASGQGSAQPPVPGSTRVSVEESTPPLASPRESVEGSAPPLTGPTSIPTPRESLNQSMASREKASVAGHMFDVVVIGGGISGLSAAKLLAEHEVNVLVLEARDRVGGRTYTVRNEHVNYVDVGGAYVGPTQNRILRLSKELGLETYKVNVCERLVQYVKGKTYPFRGAFPPVWNPVAYLDYNNLWRTMDNMGKEIPADAPWEAPHAKEWDKMTMKELIDKICWTKTARQFAYLFVNINVTSEPHEVSALWFLWYVKQCGGTTRIFSVTNGGQERKFVGGSGQVSERIMDRLGDRVKLKRPVTYVDQSGDSIIIETLNHEVYECRYVISAIPPTLTAKMHFKPELPSERNQLIQRLPMGSIIKCMMYYKEAFWKKNDYCGCMIIQDEEAPISITLDDTKPDGSLPAIMGFILARKADRLAKLHKEIRKKKICELYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIYFAGTETATHWSGYMEGAVEAGERAAREVLNALGKVAKKDIKVQEPESKDVPAVEITRTFWERNLPSVSGLLKIIGFTTSVTAVWIVVHKFRLLSRS

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A337SH13A0A337SH13_FELCAMAOA1178

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias29-47Polar residues
Compositional bias65-121Polar residues
Compositional bias212-246Polar residues
Compositional bias364-380Polar residues
Compositional bias424-438Polar residues
Compositional bias464-565Polar residues
Compositional bias581-603Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AANG04002273
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

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