M3WI73 · M3WI73_FELCA
- ProteinAmine oxidase
- GeneMAOA
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1126 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Catalyzes the oxidative deamination of primary and some secondary amine such as neurotransmitters, with concomitant reduction of oxygen to hydrogen peroxide and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. Preferentially oxidizes serotonin. Also catalyzes the oxidative deamination of kynuramine to 3-(2-aminophenyl)-3-oxopropanal that can spontaneously condense to 4-hydroxyquinoline.
Catalytic activity
- (R)-adrenaline + O2 + H2O = (R)-3,4-dihydroxymandelaldehyde + methylamine + H2O2
- (R)-noradrenaline + O2 + H2O = (R)-3,4-dihydroxymandelaldehyde + H2O2 + NH4+
- 2-phenylethylamine + O2 + H2O = 2-phenylacetaldehyde + H2O2 + NH4+
- serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4+
- tryptamine + O2 + H2O = indole-3-acetaldehyde + H2O2 + NH4+
- tyramine + O2 + H2O = (4-hydroxyphenyl)acetaldehyde + H2O2 + NH4+
- kynuramine + O2 + H2O = 3-(2-aminophenyl)-3-oxopropanal + H2O2 + NH4+This reaction proceeds in the forward direction.
- dopamine + O2 + H2O = 3,4-dihydroxyphenylacetaldehyde + H2O2 + NH4+
Cofactor
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial outer membrane | |
Molecular Function | aliphatic amine oxidase activity | |
Molecular Function | monoamine oxidase activity | |
Molecular Function | primary methylamine oxidase activity | |
Biological Process | catecholamine metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAmine oxidase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Feliformia > Felidae > Felinae > Felis
Accessions
- Primary accessionM3WI73
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion outer membrane ; Single-pass type IV membrane protein
Keywords
- Cellular component
PTM/Processing
Expression
Gene expression databases
Interaction
Subunit
Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer.
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-47 | Disordered | |||
Compositional bias | 29-47 | Polar residues | |||
Compositional bias | 65-121 | Polar residues | |||
Region | 65-246 | Disordered | |||
Compositional bias | 212-246 | Polar residues | |||
Region | 339-380 | Disordered | |||
Compositional bias | 364-380 | Polar residues | |||
Region | 402-441 | Disordered | |||
Compositional bias | 424-438 | Polar residues | |||
Region | 459-603 | Disordered | |||
Compositional bias | 464-565 | Polar residues | |||
Compositional bias | 581-603 | Polar residues | |||
Domain | 622-1059 | Amine oxidase | |||
Sequence similarities
Belongs to the flavin monoamine oxidase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,126
- Mass (Da)121,041
- Last updated2019-12-11 v4
- Checksum0A6792938F3BDA31
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A337SH13 | A0A337SH13_FELCA | MAOA | 1178 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 29-47 | Polar residues | |||
Compositional bias | 65-121 | Polar residues | |||
Compositional bias | 212-246 | Polar residues | |||
Compositional bias | 364-380 | Polar residues | |||
Compositional bias | 424-438 | Polar residues | |||
Compositional bias | 464-565 | Polar residues | |||
Compositional bias | 581-603 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AANG04002273 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |