M3WB34 · M3WB34_FELCA

Function

Catalytic activity

  • 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O = 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.
  • 2',3'-cGAMP(in) + ATP + H2O = 2',3'-cGAMP(out) + ADP + phosphate + H+
  • leukotriene C4(in) + ATP + H2O = leukotriene C4(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.
  • sphing-4-enine 1-phosphate(in) + ATP + H2O = sphing-4-enine 1-phosphate(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.
  • vincristine(in) + ATP + H2O = vincristine(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.
  • ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2.
    EC:7.6.2.2 (UniProtKB | ENZYME | Rhea)
  • daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.

GO annotations

AspectTerm
Cellular Componentapical plasma membrane
Cellular Componentbasolateral plasma membrane
Cellular Componentlateral plasma membrane
Molecular FunctionABC-type glutathione S-conjugate transporter activity
Molecular FunctionABC-type xenobiotic transporter activity
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionATPase-coupled lipid transmembrane transporter activity
Molecular Functioncarboxylic acid transmembrane transporter activity
Molecular Functionefflux transmembrane transporter activity
Molecular Functionglutathione transmembrane transporter activity
Biological Processcyclic nucleotide transport
Biological Processexport across plasma membrane
Biological Processglutathione transmembrane transport
Biological Processphospholipid translocation
Biological Processsphingolipid translocation
Biological Processtransepithelial transport
Biological Processxenobiotic transport
Biological Processxenobiotic transport across blood-brain barrier

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Multidrug resistance-associated protein 1
  • EC number
  • Alternative names
    • ATP-binding cassette sub-family C member 1
    • Glutathione-S-conjugate-translocating ATPase ABCC1
    • Leukotriene C(4) transporter

Gene names

    • Name
      ABCC1

Organism names

  • Taxonomic identifier
  • Strain
    • Abyssinian
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Feliformia > Felidae > Felinae > Felis

Accessions

  • Primary accession
    M3WB34

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane37-58Helical
Transmembrane94-111Helical
Transmembrane131-149Helical
Transmembrane274-292Helical
Transmembrane322-343Helical
Transmembrane395-417Helical
Transmembrane423-443Helical
Transmembrane501-529Helical
Transmembrane541-565Helical
Transmembrane924-951Helical
Transmembrane971-999Helical
Transmembrane1053-1084Helical

Keywords

  • Cellular component

PTM/Processing

Proteomic databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, compositional bias, region.

Type
IDPosition(s)Description
Domain284-566ABC transmembrane type-1
Domain602-826ABC transporter
Compositional bias872-892Polar residues
Region872-897Disordered
Domain931-1211ABC transmembrane type-1
Domain1248-1482ABC transporter

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,486
  • Mass (Da)
    166,404
  • Last updated
    2019-12-11 v4
  • Checksum
    9806B5B0B7BF202B
MALRGFCSADGSDPFWEWSVTWNTSNPDFTKCFQNTVLVWVPCSYLWVCFPFYFLYLCHHDRGYIQMTYLNKTKTLLATFLIQLERRKGVQSSGIMLTFWLVALLCALAILRSKIMTALKEGAEIDVFRDVTFYIYFSLVLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRVTFWWITGLMVRGYRQPLESTDLWSLNKEDTSEQVVPILVKNWKKECAKSRRQQAKIAYSSKDPAKPKGSSQVDVNEEAEVLIVKSPQKGREPSLFKVLYKTFGPYFLMSFLFKALHDLMMFAGPEILKLLINFVNDTTAPDWQGYFYTALLFVSACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARRSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVVLALYLLWLNLGPSVLAGVAVMIFMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLAAVGTFTWVCTPFLVALSTFAVYVTVNENNILDAQKAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEADSIERKPGKDGGGTNSITVKNATFTWARSDPPMLNGITFSVPEGSLVAVVGQVGCGKSSLLSALLAEMDKVEGHVSVKGSVAYVPQQAWIQNDSLRENILFGRPLQERYYKAVIEACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYCDSDIYLFDDPLSAVDAHVGKHIFENVVGPKGMLKNKTRLLVTHSISYLPQVDVIIVMTGGKISEMGSYQELLARDGAFAEFLRTYAGTEQEQSEQDDGISSPGKETKQMENGMLVTDVAGKQLQRQLSNSSSYSGDVSRHHTSTAEPQKAGAQDEDTWKLVEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFLCNHVAALASNYWLSLWTDDPIVNGTQEHTKVRLSVYGALGILQGISVFGYSMLLSIGGIFASRRLHLNLLQNVLRSPMSFFERTPSGNLVNRFSKELDTVDSMIPQVIKMFMGSLFNVIGACTIILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIRQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSELETNIVAVERLKEYSETEKEAPWQIPETAPPSTWPQVGRVEFRDYGLRYRENLDLVLKHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDDINIAKIGLHDLRFRITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLNHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFDDCTVLTIAHRLNTIMDYTRVIVLDKGEIRECGHPLDLLQERGLFYSMAKDAGLV

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias872-892Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AANG04001668
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

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