M3WB34 · M3WB34_FELCA
- ProteinMultidrug resistance-associated protein 1
- GeneABCC1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1486 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
Catalytic activity
- 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O = 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.
- 2',3'-cGAMP(in) + ATP + H2O = 2',3'-cGAMP(out) + ADP + phosphate + H+
- leukotriene C4(in) + ATP + H2O = leukotriene C4(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.
- sphing-4-enine 1-phosphate(in) + ATP + H2O = sphing-4-enine 1-phosphate(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.
- vincristine(in) + ATP + H2O = vincristine(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.
- daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | apical plasma membrane | |
Cellular Component | basolateral plasma membrane | |
Cellular Component | lateral plasma membrane | |
Molecular Function | ABC-type glutathione S-conjugate transporter activity | |
Molecular Function | ABC-type xenobiotic transporter activity | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | ATPase-coupled lipid transmembrane transporter activity | |
Molecular Function | carboxylic acid transmembrane transporter activity | |
Molecular Function | efflux transmembrane transporter activity | |
Molecular Function | glutathione transmembrane transporter activity | |
Biological Process | cyclic nucleotide transport | |
Biological Process | export across plasma membrane | |
Biological Process | glutathione transmembrane transport | |
Biological Process | phospholipid translocation | |
Biological Process | sphingolipid translocation | |
Biological Process | transepithelial transport | |
Biological Process | xenobiotic transport | |
Biological Process | xenobiotic transport across blood-brain barrier |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMultidrug resistance-associated protein 1
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Feliformia > Felidae > Felinae > Felis
Accessions
- Primary accessionM3WB34
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 37-58 | Helical | |||
Transmembrane | 94-111 | Helical | |||
Transmembrane | 131-149 | Helical | |||
Transmembrane | 274-292 | Helical | |||
Transmembrane | 322-343 | Helical | |||
Transmembrane | 395-417 | Helical | |||
Transmembrane | 423-443 | Helical | |||
Transmembrane | 501-529 | Helical | |||
Transmembrane | 541-565 | Helical | |||
Transmembrane | 924-951 | Helical | |||
Transmembrane | 971-999 | Helical | |||
Transmembrane | 1053-1084 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Proteomic databases
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, compositional bias, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 284-566 | ABC transmembrane type-1 | |||
Domain | 602-826 | ABC transporter | |||
Compositional bias | 872-892 | Polar residues | |||
Region | 872-897 | Disordered | |||
Domain | 931-1211 | ABC transmembrane type-1 | |||
Domain | 1248-1482 | ABC transporter | |||
Sequence similarities
Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,486
- Mass (Da)166,404
- Last updated2019-12-11 v4
- Checksum9806B5B0B7BF202B
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 872-892 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AANG04001668 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |