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M3W4W0 · M3W4W0_FELCA

Function

Catalytic activity

  • All bonds known to be hydrolyzed by this endopeptidase have arginine in P1 and an acidic residue in P4. P6 is often occupied by an acidic residue or by a hydroxy-amino-acid residue, the phosphorylation of which enhances cleavage.
    EC:3.4.22.49 (UniProtKB | ENZYME | Rhea)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcentrosome
Cellular Componentcytoplasm
Cellular Componentmitotic spindle
Cellular Componentnucleus
Molecular Functioncysteine-type endopeptidase activity
Biological Processhomologous chromosome segregation
Biological Processmeiotic chromosome separation
Biological Processmeiotic spindle organization
Biological Processmitotic sister chromatid segregation
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    separase
  • EC number

Gene names

    • Name
      ESPL1

Organism names

  • Taxonomic identifier
  • Strain
    • Abyssinian
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Feliformia > Felidae > Felinae > Felis

Accessions

  • Primary accession
    M3W4W0

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Proteomic databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region1293-1356Disordered
Compositional bias1304-1334Polar residues
Region1372-1467Disordered
Compositional bias1392-1419Basic and acidic residues
Region1499-1549Disordered
Compositional bias1522-1549Basic and acidic residues
Domain1937-2032Peptidase C50

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    2,112
  • Mass (Da)
    231,383
  • Last updated
    2018-02-28 v2
  • MD5 Checksum
    521B2F20AC95B293B0EC27C708B38EAE
MRSFKGINFGTLLSSVKEAEELLPDLKEFLSKLPAGSNSCRSDAERRQACDAILRACNQQLTAKLACPRHLESLLELAELAYNGYLMSTPQRPPLYLERILFIFLRNIATQGIPEATLRFAKPLHACLVHCSRQAAPQDYDAVARGSFSLLWKAAETLEERRAALSTRLKALSFLVLLEDESTPCEVPHFASPTACRVVAAHQLFDATGHSLNEADADFLDDLLSRHVIKVLVGEGGGSPGPLSPQRALCLLELTLERCRRLCWSGHHAKATRVVEKTHDYLRNTSLAPSLQLCQLGVELLQAGEGGSQALAELLIKASAVLNNSVEAPSPPLRALCDSCQFFLSGLERGIKRRYGLDAVLGLFAFLGGYCSLIRQLQDGVCGDSSKQQQSLVQMHFQGLHLYTVVVYDFAQSCQVADLADLAQLVESCKSTVVWMLEALQSLSGQELTDYLGMTASYTSNLAYSFYSHKLYSEACAISEPLCQHLGLVKPDMYPEVPPEKLHRCFRLHGESLKKLGKQAQGCEMVTLWLTALQPCGPQHMAEPVTFWVRIKMDAARAGDKELQLRTLRDSLSGWDPETLVFLLREELQAYKAVRADTGQERFNVICDLLELSPEETPAGAWARATHLVELAQVLCYHDFAQQTNCSALDAIQEALQLLESVRPETQAKDRLLDDKAQALLWFYICTLETKMQEGIERDRRAQAPNNLEEFEVNDLNYEDKLQEDRFLYSNIAFNLAADAAQSKCLDQALALWKEVLTKAQAPAVRCLQQTAASLQTLAALYQLAAKPLQALEVLLLVRIVSQRLEDHAKAAGSSCHASQLLLMLGCPSYAQLYLEEADSSLKLLDHNTDTYLLLSLTCNLLRSQLYCVHQKVTEGASLLLSVLRDPALQRSSKAWYLLRVQALQVVASYLSLSSDSLSASLREQLCAQGWQTPEIALVDSHKLLRSIILLLLGSDVLSIQKAAVETPFLDYGENLVQKWQVLTEVLSCSEKLVSRLGHLGCVSEAKAFCLDALKLTTKLQLPHQCALFLVLKAELELARTDIDLCESDLQQVLFLLESCTEFGGLAQHLDSVKKVHLQKGKQQTRVRRPPELPEEEPFLRGPALELVATVAKEPGPVAPSTNSSPVLKAKPQPSPGFLTHLPTCDCLLCASPVLSAVCLRWALVTAGVRLALGHQAQGLDLLQVVLKGCPAATERLTQALQTTLNHKAPPSPVPSLLDEILAQAYTQLALEGLSRPSHKSLGKVLESGLKFVAARVPHLEPWRASLLLIRALAKLAGLNCCTTQLFASSWGWQPPSVKPSPGSEPSKPRSQKLSGRGRQRAASSTQPLHNTSLKSLEGGGLPCTPKPPGQVRPAGTRVPFTVFEEVLPTKSKPEVPKAPRVQQRVQTRLKVNFSDDSDLEDPVSIEARPAEGPKRRGTASRGRGRGRGQARKNPSLKTVAVAASSSAPGLPGLGGRSRRAKKVTSGHCEELGSEIIRTIPEEEMTDNQMEMSFEILRGSDGEDSASGGKAPAPGPDTAIGECEVLRRDSSKEELPVPCPDKERDKDLGPRLRLSSAPVAIGLSTLDSICDLLTIAFRGVSHCPPSGLYAYLCRLLALCLGHRDPYATACLVTESVSITCRHQLLTHLHRQLSKAQKHRGSLEMADQVQRLSLQDRPGDVPLARIQHLFSFRASGSGQFPEPEKESFQERLALIPSGVTVCVLALATLQPGTVGNTLLLTRLEKDNPPVTVQIPTAQSKLPLSSALKEFDTIQKEQKENSSCTDKREWWTGRLELDHRMEALIISLEKHVLGCWRGLLLPSSEDPGPAQEASRLQKLLQECGWEYPDAALLKTMLSGASTLTPQDIETLAYGLCPAWPERAQELLSEAVRRLQGQTVPSNRHLVLVLDKDLQKLPWESIPSLRALPVTRLPSFHFLLSYSIIRESGASAVLSQGVDPRNTFYVLNPHNNLSSTEEQFRANFSSEAGWKGVVGEVPSPEQVQAALTEHDLYIYAGHGAGARFLDGQAVLRLGCRAVALLFGCSSAALAVHGNLEGAGIVLKYIMAGCPLFLGNLWDVTDRDIDRYTEALLQGWLGAGPGAPLLYYVNQARQAPRLKYLIGAAPVAYGLPVSLR

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1304-1334Polar residues
Compositional bias1392-1419Basic and acidic residues
Compositional bias1522-1549Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AANG04001751
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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