M3VX94 · M3VX94_FELCA
- Protein10-formyltetrahydrofolate dehydrogenase
- GeneALDH1L1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids902 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- (6R)-10-formyltetrahydrofolate + NADP+ + H2O = (6S)-5,6,7,8-tetrahydrofolate + CO2 + NADPH + H+This reaction proceeds in the forward direction.
Features
Showing features for binding site, active site, site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 88-90 | (6R)-10-formyltetrahydrofolate (UniProtKB | ChEBI) | |||
Active site | 106 | Proton donor | |||
Binding site | 142 | (6R)-10-formyltetrahydrofolate (UniProtKB | ChEBI) | |||
Site | 142 | Essential for catalytic activity | |||
Binding site | 571-573 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 597-600 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 630-635 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 650-651 | NADP+ (UniProtKB | ChEBI) | |||
Active site | 673 | ||||
Active site | 673 | Proton acceptor | |||
Active site | 707 | Proton donor | |||
Binding site | 757 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 804-806 | NADP+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | formyltetrahydrofolate dehydrogenase activity | |
Molecular Function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor | |
Biological Process | 10-formyltetrahydrofolate catabolic process | |
Biological Process | biosynthetic process | |
Biological Process | one-carbon metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name10-formyltetrahydrofolate dehydrogenase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Feliformia > Felidae > Felinae > Felis
Accessions
- Primary accessionM3VX94
Proteomes
Subcellular Location
PTM/Processing
Expression
Gene expression databases
Interaction
Subunit
Homotetramer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 318-395 | Carrier | |||
Sequence similarities
Belongs to the aldehyde dehydrogenase family.
In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.
In the N-terminal section; belongs to the GART family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length902
- Mass (Da)98,839
- Last updated2019-12-11 v4
- MD5 Checksum9F80462A2EE24F1FB9B029383210DF49
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A337RUT4 | A0A337RUT4_FELCA | ALDH1L1 | 907 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AANG04002863 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |