M3VWT0 · M3VWT0_FELCA
- ProteinTriacylglycerol lipase
- GenePNLIPRP1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids469 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
Catalytic activity
- (9Z-octadecenoyl)-glycerol + H2O = glycerol + (9Z)-octadecenoate + H+This reaction proceeds in the forward direction.
- 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = di-(9Z)-octadecenoylglycerol + (9Z)-octadecenoate + H+This reaction proceeds in the forward direction.
- 1,2,3-tributanoylglycerol + H2O = dibutanoylglycerol + butanoate + H+This reaction proceeds in the forward direction.
- 1,2,3-trioctanoylglycerol + H2O = dioctanoylglycerol + octanoate + H+This reaction proceeds in the forward direction.
- 1,2,3-tripropanoylglycerol + H2O = dipropanoylglycerol + propanoate + H+This reaction proceeds in the forward direction.
- a 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O = acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + a fatty acid + H+This reaction proceeds in the forward direction.
- 1,2-didecanoylglycerol + H2O = decanoylglycerol + decanoate + H+This reaction proceeds in the forward direction.
- 1,2-didodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O = dodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + dodecanoate + H+This reaction proceeds in the forward direction.
- 1,2-didodecanoyl-3-beta-D-galactosyl-sn-glycerol + H2O = dodecanoyl-3-beta-D-galactosyl-sn-glycerol + dodecanoate + H+This reaction proceeds in the forward direction.
- 1,2-dioctanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O = octanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + octanoate + H+This reaction proceeds in the forward direction.
- 1,2-dioctanoyl-3-O-beta-D-galactosyl-sn-glycerol + H2O = octanoyl-3-(beta-D-galactosyl)-sn-glycerol + octanoate + H+This reaction proceeds in the forward direction.
- 1-(9Z-octadecenoyl)-glycerol + H2O = glycerol + (9Z)-octadecenoate + H+This reaction proceeds in the forward direction.
- 1-beta-D-galactosyl-2,3-didodecanoyl-sn-glycerol + H2O = 1-beta-D-galactosyl-dodecanoyl-sn-glycerol + dodecanoate + H+This reaction proceeds in the forward direction.
- long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O = long chain acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + a fatty acid + H+This reaction proceeds in the forward direction.
- long chain 1,2-diacyl-3-O-beta-D-galactosyl-sn-glycerol + H2O = long chain acyl-3-O-beta-D-galactosyl-sn-glycerol + a fatty acid + H+This reaction proceeds in the forward direction.
- a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a monoacyl-sn-glycero-3-phosphocholine + a fatty acid + H+This reaction proceeds in the forward direction.
- di-(9Z)-octadecenoylglycerol + H2O = (9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H+This reaction proceeds in the forward direction.
Pathway
Glycerolipid metabolism; triacylglycerol degradation.
Glycolipid metabolism.
Lipid metabolism.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 171 | Nucleophile | |||
Active site | 195 | Charge relay system | |||
Binding site | 206 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 209 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 211 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 214 | Ca2+ (UniProtKB | ChEBI) | |||
Active site | 282 | Charge relay system | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Cellular Component | neuron projection | |
Cellular Component | zymogen granule membrane | |
Molecular Function | galactolipase activity | |
Molecular Function | metal ion binding | |
Molecular Function | triacylglycerol lipase activity | |
Biological Process | lipid catabolic process |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameTriacylglycerol lipase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Feliformia > Felidae > Felinae > Felis
Accessions
- Primary accessionM3VWT0
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Zymogen granule membrane ; Peripheral membrane protein
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-17 | ||||
Chain | PRO_5005140382 | 18-469 | Triacylglycerol lipase | ||
Disulfide bond | 21↔27 | ||||
Disulfide bond | 109↔120 | ||||
Disulfide bond | 256↔280 | ||||
Disulfide bond | 304↔315 | ||||
Disulfide bond | 318↔323 | ||||
Disulfide bond | 453↔469 | ||||
Keywords
- PTM
Proteomic databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 357-469 | PLAT | |||
Sequence similarities
Belongs to the AB hydrolase superfamily. Lipase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length469
- Mass (Da)52,330
- Last updated2013-05-01 v1
- Checksum5BB59993AB3D3230
Computationally mapped potential isoform sequences
There are 6 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
M3WPS6 | M3WPS6_FELCA | PNLIPRP1 | 467 | ||
A0A5F5XSU9 | A0A5F5XSU9_FELCA | PNLIPRP1 | 495 | ||
A0A5F5Y5N1 | A0A5F5Y5N1_FELCA | PNLIPRP1 | 467 | ||
A0A5F5Y684 | A0A5F5Y684_FELCA | PNLIPRP1 | 486 | ||
A0A5F5Y7A4 | A0A5F5Y7A4_FELCA | PNLIPRP1 | 467 | ||
A0A0A0MPX7 | A0A0A0MPX7_FELCA | PNLIPRP1 | 465 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AANG04000273 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |