M3VWT0 · M3VWT0_FELCA

Function

Catalytic activity

  • (9Z-octadecenoyl)-glycerol + H2O = glycerol + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = di-(9Z)-octadecenoylglycerol + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • 1,2,3-tributanoylglycerol + H2O = dibutanoylglycerol + butanoate + H+
    This reaction proceeds in the forward direction.
  • 1,2,3-trioctanoylglycerol + H2O = dioctanoylglycerol + octanoate + H+
    This reaction proceeds in the forward direction.
  • 1,2,3-tripropanoylglycerol + H2O = dipropanoylglycerol + propanoate + H+
    This reaction proceeds in the forward direction.
  • a 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O = acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + a fatty acid + H+
    This reaction proceeds in the forward direction.
  • 1,2-didecanoylglycerol + H2O = decanoylglycerol + decanoate + H+
    This reaction proceeds in the forward direction.
  • 1,2-didodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O = dodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + dodecanoate + H+
    This reaction proceeds in the forward direction.
  • 1,2-didodecanoyl-3-beta-D-galactosyl-sn-glycerol + H2O = dodecanoyl-3-beta-D-galactosyl-sn-glycerol + dodecanoate + H+
    This reaction proceeds in the forward direction.
  • 1,2-dioctanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O = octanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + octanoate + H+
    This reaction proceeds in the forward direction.
  • 1,2-dioctanoyl-3-O-beta-D-galactosyl-sn-glycerol + H2O = octanoyl-3-(beta-D-galactosyl)-sn-glycerol + octanoate + H+
    This reaction proceeds in the forward direction.
  • 1-(9Z-octadecenoyl)-glycerol + H2O = glycerol + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • 1-beta-D-galactosyl-2,3-didodecanoyl-sn-glycerol + H2O = 1-beta-D-galactosyl-dodecanoyl-sn-glycerol + dodecanoate + H+
    This reaction proceeds in the forward direction.
  • long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O = long chain acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + a fatty acid + H+
    This reaction proceeds in the forward direction.
  • long chain 1,2-diacyl-3-O-beta-D-galactosyl-sn-glycerol + H2O = long chain acyl-3-O-beta-D-galactosyl-sn-glycerol + a fatty acid + H+
    This reaction proceeds in the forward direction.
  • a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + 2 H2O = 3-beta-D-galactosyl-sn-glycerol + 2 a fatty acid + 2 H+
    This reaction proceeds in the forward direction.
    EC:3.1.1.26 (UniProtKB | ENZYME | Rhea)
  • a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a monoacyl-sn-glycero-3-phosphocholine + a fatty acid + H+
    This reaction proceeds in the forward direction.
  • a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H+
    This reaction proceeds in the forward direction.
    EC:3.1.1.3 (UniProtKB | ENZYME | Rhea)
  • di-(9Z)-octadecenoylglycerol + H2O = (9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.

Pathway

Glycerolipid metabolism; triacylglycerol degradation.
Glycolipid metabolism.
Lipid metabolism.

Features

Showing features for active site, binding site.

Type
IDPosition(s)Description
Active site171Nucleophile
Active site195Charge relay system
Binding site206Ca2+ (UniProtKB | ChEBI)
Binding site209Ca2+ (UniProtKB | ChEBI)
Binding site211Ca2+ (UniProtKB | ChEBI)
Binding site214Ca2+ (UniProtKB | ChEBI)
Active site282Charge relay system

GO annotations

AspectTerm
Cellular Componentextracellular region
Cellular Componentneuron projection
Cellular Componentzymogen granule membrane
Molecular Functiongalactolipase activity
Molecular Functionmetal ion binding
Molecular Functiontriacylglycerol lipase activity
Biological Processlipid catabolic process

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Triacylglycerol lipase
  • EC number
  • Alternative names
    • Pancreatic lipase

Gene names

    • Name
      PNLIPRP1

Organism names

  • Taxonomic identifier
  • Strain
    • Abyssinian
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Feliformia > Felidae > Felinae > Felis

Accessions

  • Primary accession
    M3VWT0

Proteomes

Subcellular Location

Secreted
Zymogen granule membrane
; Peripheral membrane protein

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

Type
IDPosition(s)Description
Signal1-17
ChainPRO_500514038218-469Triacylglycerol lipase
Disulfide bond21↔27
Disulfide bond109↔120
Disulfide bond256↔280
Disulfide bond304↔315
Disulfide bond318↔323
Disulfide bond453↔469

Keywords

Proteomic databases

Expression

Gene expression databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain357-469PLAT

Sequence similarities

Belongs to the AB hydrolase superfamily. Lipase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    469
  • Mass (Da)
    52,330
  • Last updated
    2013-05-01 v1
  • Checksum
    5BB59993AB3D3230
MLPSWTIGLLLLATVRGKEICYGHLGCFSDGKPWTGILQRPLKLFPWAPKDIDTRFLLYTNENPNNFQLITATDLETVEASNFQLERKTRFIIHGFIDKGEESWLLDMCKKMFQVEKVNCICVDWRRGAKTQYTQAVHNIRVVGAEIAFLIQRLSTELGYGPEDVHLIGHSLGAHAAAEAGRRLGGRVGRITGLDPAEPCFQGTPEEVRLDASDAMFVDVIHTDSAPMIPFLGFGMSQKVGHLDFYPNGGKQMPGCQKNALSTIVDINGLWEGTRDFVACNHLRSYKYYSSSITSPDGFLGYPCASYNDFQEGNCFPCPPEGCPQMGHYADQFQGKTRAVGQTFFLNTGDSGNFTRWRHRVSVTLAGKRKTSGYFRIALYGSNGNSKQYEIFKGSLQPRASHMRDIDVDVNVGKIQKVKFLWNNHVINLIRPKLGASQITVQSGENGTEYNFCSNDAVSEDVLQSLYAC

Computationally mapped potential isoform sequences

There are 6 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
M3WPS6M3WPS6_FELCAPNLIPRP1467
A0A5F5XSU9A0A5F5XSU9_FELCAPNLIPRP1495
A0A5F5Y5N1A0A5F5Y5N1_FELCAPNLIPRP1467
A0A5F5Y684A0A5F5Y684_FELCAPNLIPRP1486
A0A5F5Y7A4A0A5F5Y7A4_FELCAPNLIPRP1467
A0A0A0MPX7A0A0A0MPX7_FELCAPNLIPRP1465

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AANG04000273
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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