M3VWS9 · M3VWS9_FELCA
- ProteinGlutathione hydrolase
- GeneGGT1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids568 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.
Catalytic activity
- an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate
Pathway
Sulfur metabolism; glutathione metabolism.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 106 | L-glutamate (UniProtKB | ChEBI) | |||
Active site | 380 | Nucleophile | |||
Binding site | 398-400 | L-glutamate (UniProtKB | ChEBI) | |||
Binding site | 422 | L-glutamate (UniProtKB | ChEBI) | |||
Binding site | 450-451 | L-glutamate (UniProtKB | ChEBI) | |||
Binding site | 473 | L-glutamate (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Cellular Component | vesicle | |
Molecular Function | acyltransferase activity | |
Molecular Function | glutathione hydrolase activity | |
Biological Process | cysteine biosynthetic process | |
Biological Process | glutathione biosynthetic process | |
Biological Process | glutathione catabolic process | |
Biological Process | peptide modification | |
Biological Process | regulation of immune system process | |
Biological Process | regulation of inflammatory response | |
Biological Process | spermatogenesis |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGlutathione hydrolase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Feliformia > Felidae > Felinae > Felis
Accessions
- Primary accessionM3VWS9
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Single-pass type II membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 6-29 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Proteomic databases
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length568
- Mass (Da)61,396
- Last updated2013-05-01 v1
- Checksum8CDEFB51167A3BD3
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AANG04002472 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |