M3VWS9 · M3VWS9_FELCA

Function

function

Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.

Catalytic activity

Pathway

Sulfur metabolism; glutathione metabolism.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site106L-glutamate (UniProtKB | ChEBI)
Active site380Nucleophile
Binding site398-400L-glutamate (UniProtKB | ChEBI)
Binding site422L-glutamate (UniProtKB | ChEBI)
Binding site450-451L-glutamate (UniProtKB | ChEBI)
Binding site473L-glutamate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentplasma membrane
Cellular Componentvesicle
Molecular Functionacyltransferase activity
Molecular Functionglutathione hydrolase activity
Biological Processcysteine biosynthetic process
Biological Processglutathione biosynthetic process
Biological Processglutathione catabolic process
Biological Processpeptide modification
Biological Processregulation of immune system process
Biological Processregulation of inflammatory response
Biological Processspermatogenesis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Glutathione hydrolase
  • EC number
  • Alternative names
    • Gamma-glutamyltransferase
    • Gamma-glutamyltranspeptidase

Gene names

    • Name
      GGT1

Organism names

  • Taxonomic identifier
  • Strain
    • Abyssinian
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Feliformia > Felidae > Felinae > Felis

Accessions

  • Primary accession
    M3VWS9

Proteomes

Subcellular Location

Membrane
; Single-pass type II membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane6-29Helical

Keywords

  • Cellular component

PTM/Processing

Proteomic databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the gamma-glutamyltransferase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    568
  • Mass (Da)
    61,396
  • Last updated
    2013-05-01 v1
  • Checksum
    8CDEFB51167A3BD3
MKKRYVVLALLAVVLVIFIIILCLCLLLTSKPQSHIYPRAAVATDAKYCSEIGRDMLRDGGSAVDAAIAALLCVGLMNAHSMGIGGGLFLTIYNSTTRKVEIINAREVAPGLASEGMFNSPEQSQKGGLSVAVPGEIRGYELAHQRHGRLPWAHLFQPSIQLARQGFPVGKGLAVALEKNRAVIEEQPALCEVFCRDGKVLREGDRLTMPQLANTYETLALEGAQAFYNGSLTAQIVKDIQAAGGIMTTKDLNNYRAELIEQPLNISLGDAQLYVPSAPLSGPVLALILNILKGYNFSPASVETPEQKGLTYHRIVEAFRFAYAKRTLLGDPKFVNMMEVVRNMSSEFFAAQLRARISDDTTHPFPYYEPEFYTPDDGGTAHLSVVAEDGSAVSATSTINLQFGSKVRSRVSGILFNDEMDDFSSPNITNQFGVPPSPANFIKPGKQPVSSMCPAIIVGRDGQVRMVVGASGGTKITTATALTIIHSLWFGYDLKRAVEEPRLHNQLLPNTTTLEKDTDQAVVAALKTRHHHAEITSNFIAVVQAIVHTAGGWAAASDSRKGGEPAGY

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AANG04002472
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

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