M3VWP3 · M3VWP3_FELCA
- Protein10-formyltetrahydrofolate dehydrogenase
- GeneALDH1L2
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids923 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- (6R)-10-formyltetrahydrofolate + NADP+ + H2O = (6S)-5,6,7,8-tetrahydrofolate + CO2 + NADPH + H+This reaction proceeds in the forward direction.
Features
Showing features for binding site, active site, site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 110-112 | (6R)-10-formyltetrahydrofolate (UniProtKB | ChEBI) | |||
Active site | 128 | Proton donor | |||
Binding site | 164 | (6R)-10-formyltetrahydrofolate (UniProtKB | ChEBI) | |||
Site | 164 | Essential for catalytic activity | |||
Binding site | 592-594 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 618-621 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 651-656 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 671-672 | NADP+ (UniProtKB | ChEBI) | |||
Active site | 694 | ||||
Active site | 694 | Proton acceptor | |||
Active site | 728 | Proton donor | |||
Binding site | 778 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 825-827 | NADP+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrion | |
Cellular Component | nucleoplasm | |
Molecular Function | aldehyde dehydrogenase (NAD+) activity | |
Molecular Function | formyltetrahydrofolate dehydrogenase activity | |
Biological Process | 10-formyltetrahydrofolate catabolic process | |
Biological Process | biosynthetic process | |
Biological Process | fatty acid beta-oxidation | |
Biological Process | folic acid metabolic process | |
Biological Process | NADPH regeneration | |
Biological Process | one-carbon metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name10-formyltetrahydrofolate dehydrogenase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Feliformia > Felidae > Felinae > Felis
Accessions
- Primary accessionM3VWP3
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 339-416 | Carrier | |||
Sequence similarities
Belongs to the aldehyde dehydrogenase family.
In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.
In the N-terminal section; belongs to the GART family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length923
- Mass (Da)101,646
- Last updated2018-10-10 v3
- MD5 Checksum23821B5C2ECF0F6B908E1422D2B8B625
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AANG04003655 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |