M3FEV6 · M3FEV6_9ACTN
- ProteinGlycerol kinase
- GeneglpK
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids519 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
Catalytic activity
- glycerol + ATP = sn-glycerol 3-phosphate + ADP + H+
Activity regulation
Inhibited by fructose 1,6-bisphosphate (FBP).
Pathway
Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 25 | ADP (UniProtKB | ChEBI) | |||
Binding site | 25 | ATP (UniProtKB | ChEBI) | |||
Binding site | 25 | sn-glycerol 3-phosphate (UniProtKB | ChEBI) | |||
Binding site | 26 | ATP (UniProtKB | ChEBI) | |||
Binding site | 27 | ATP (UniProtKB | ChEBI) | |||
Binding site | 29 | ADP (UniProtKB | ChEBI) | |||
Binding site | 95 | glycerol (UniProtKB | ChEBI) | |||
Binding site | 95 | sn-glycerol 3-phosphate (UniProtKB | ChEBI) | |||
Binding site | 96 | glycerol (UniProtKB | ChEBI) | |||
Binding site | 96 | sn-glycerol 3-phosphate (UniProtKB | ChEBI) | |||
Binding site | 147 | glycerol (UniProtKB | ChEBI) | |||
Binding site | 147 | sn-glycerol 3-phosphate (UniProtKB | ChEBI) | |||
Binding site | 262 | glycerol (UniProtKB | ChEBI) | |||
Binding site | 262 | sn-glycerol 3-phosphate (UniProtKB | ChEBI) | |||
Binding site | 263 | glycerol (UniProtKB | ChEBI) | |||
Binding site | 284 | ADP (UniProtKB | ChEBI) | |||
Binding site | 284 | ATP (UniProtKB | ChEBI) | |||
Binding site | 328 | ADP (UniProtKB | ChEBI) | |||
Binding site | 328 | ATP (UniProtKB | ChEBI) | |||
Binding site | 332 | ATP (UniProtKB | ChEBI) | |||
Binding site | 429 | ADP (UniProtKB | ChEBI) | |||
Binding site | 429 | ATP (UniProtKB | ChEBI) | |||
Binding site | 433 | ADP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | ATP binding | |
Molecular Function | glycerol kinase activity | |
Biological Process | glycerol catabolic process | |
Biological Process | glycerol-3-phosphate metabolic process | |
Biological Process | phosphorylation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGlycerol kinase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Kitasatosporales > Streptomycetaceae > Streptomyces
Accessions
- Primary accessionM3FEV6
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 18-269 | Carbohydrate kinase FGGY N-terminal | |||
Domain | 279-468 | Carbohydrate kinase FGGY C-terminal | |||
Sequence similarities
Belongs to the FGGY kinase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length519
- Mass (Da)56,890
- Last updated2013-05-01 v1
- ChecksumFC759F7D088B2CB7
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KB405096 EMBL· GenBank· DDBJ | EMF51400.1 EMBL· GenBank· DDBJ | Genomic DNA |