M3F0J7 · M3F0J7_9ACTN

Function

function

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular FunctionNADH dehydrogenase activity
Molecular Functionoxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
Molecular Functionquinone binding
Biological Processaerobic respiration

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADH-quinone oxidoreductase subunit H
  • EC number
  • Alternative names
    • NADH dehydrogenase I subunit H
    • NDH-1 subunit H

Gene names

    • Name
      nuoH
    • ORF names
      SBD_3573

Organism names

Accessions

  • Primary accession
    M3F0J7

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane63-86Helical
Transmembrane106-129Helical
Transmembrane150-174Helical
Transmembrane180-199Helical
Transmembrane236-254Helical
Transmembrane274-294Helical
Transmembrane306-326Helical
Transmembrane338-359Helical

Keywords

PTM/Processing

Keywords

Interaction

Subunit

NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.

Family & Domains

Features

Showing features for region, compositional bias.

Type
IDPosition(s)Description
Region370-428Disordered
Compositional bias379-395Pro residues
Compositional bias396-410Basic and acidic residues

Sequence similarities

Belongs to the complex I subunit 1 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    428
  • Mass (Da)
    47,394
  • Last updated
    2013-05-01 v1
  • MD5 Checksum
    8AB55ED4DE3AE46ADBFA3ACB421858CA
MFCFAFLMVTVLFSIVWERKVVAWMQLRIGPNRHGPWGMLQSLADGIKLMLKEDVIVKRADKVVYVLAPIVAAIPAFMAIAVIPFGPAGNEISIFGQRTTMQLTDLPIAMLYILAVASVGIYGIVLAGWSSGSTYPLLGGLRSAAQMISYEIAMGAAFASVFLYSGSMSTSAIVEAQQDRWYIVLLPVSFVIYIVTMVGETNRAPFDMPESEGDLVGGFNTEYSSIKFAMFMLAEYVNMVTVSAVSVTLFLGGWRAPWPISTFWEGANHGWWPMLWFVVKVQLLLFFFIWLRGTLPRVRYDQLMKLGWKVLLPVSVVWLMLVATVRTLRNENYDFAEIALYVAGAVIVLFLLSVVADMFRDRREAQDQPAEPAAFDPMAGGFPVPPLPGQTLPPVPRRRPRRERELIVSGGSDTDSDGSSNGREASDG

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias379-395Pro residues
Compositional bias396-410Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KB405071
EMBL· GenBank· DDBJ
EMF55033.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help