M3E5F1 · M3E5F1_9ACTN
- ProteinCytochrome c oxidase subunit 1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids564 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
Catalytic activity
- 4 Fe(II)-[cytochrome c] + O2 + 8 H+(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H+(out)
4 RHEA-COMP:10350 + CHEBI:15379 + 8 H+ (in)CHEBI:15378= 4 RHEA-COMP:14399 + 2 CHEBI:15377 + 4 H+ (out)CHEBI:15378
Pathway
Energy metabolism; oxidative phosphorylation.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | electron transport coupled proton transport | |
Biological Process | oxidative phosphorylation | |
Biological Process | respiratory electron transport chain |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 1
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Kitasatosporales > Streptomycetaceae > Streptomyces
Accessions
- Primary accessionM3E5F1
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 25-44 | Helical | ||||
Sequence: LYLVTSFLFFLAAGLMALVM | ||||||
Transmembrane | 64-85 | Helical | ||||
Sequence: LFTLHGTIMLLLFATPTFAGFA | ||||||
Transmembrane | 106-124 | Helical | ||||
Sequence: LSYWLFLFGGLIVMGSLLV | ||||||
Transmembrane | 153-178 | Helical | ||||
Sequence: WIMGLALAGFGTILGAVNFLTTIIGM | ||||||
Transmembrane | 190-216 | Helical | ||||
Sequence: IFTWNTLFTSILILMAFPVLAAALLVL | ||||||
Transmembrane | 236-260 | Helical | ||||
Sequence: LWQHLFWFFGHPEVYIIALPFFGII | ||||||
Transmembrane | 272-295 | Helical | ||||
Sequence: IFGYLTLVGATMAITGLSVVVWAH | ||||||
Transmembrane | 301-321 | Helical | ||||
Sequence: GAVLLPFFSFMSFLIAVPTGV | ||||||
Transmembrane | 342-362 | Helical | ||||
Sequence: LWATGFLVSFLFGGLTGVILA | ||||||
Transmembrane | 374-400 | Helical | ||||
Sequence: YFVVAHFHYVVFGTVVFATFAGFYFWW | ||||||
Transmembrane | 412-434 | Helical | ||||
Sequence: LGKIQFWTLFVGFHTTFLVQHWL | ||||||
Transmembrane | 454-475 | Helical | ||||
Sequence: ALNTISTIGAFLLGMSTLPFLY |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 13-519 | Cytochrome oxidase subunit I profile | ||||
Sequence: WLTTTDHKKIGHLYLVTSFLFFLAAGLMALVMRAELARPGTQIVDNEQFNQLFTLHGTIMLLLFATPTFAGFANEIMPLQIGAPDVAFPRLNMLSYWLFLFGGLIVMGSLLVPSGPADFGWFAYAPLNSAERSPGIGADMWIMGLALAGFGTILGAVNFLTTIIGMRAPGMTMFRMPIFTWNTLFTSILILMAFPVLAAALLVLEADRRFGSQVFDAANGGALLWQHLFWFFGHPEVYIIALPFFGIITEIIPVFSRKPIFGYLTLVGATMAITGLSVVVWAHHMFATGAVLLPFFSFMSFLIAVPTGVKFFNWTGTMLKGSLSFETPMLWATGFLVSFLFGGLTGVILASPPMDFHVTDSYFVVAHFHYVVFGTVVFATFAGFYFWWPKFTGKMLDERLGKIQFWTLFVGFHTTFLVQHWLGAEGMPRRYADYLAADGFTALNTISTIGAFLLGMSTLPFLYNVWRTSRYGVPVDADDPWGYGRSLEWATSCPPPRHNFVTLPRVR | ||||||
Region | 533-564 | Disordered | ||||
Sequence: AAITPPQTRKGQGRTPHPRFGQERPTGGPGES |
Sequence similarities
Belongs to the heme-copper respiratory oxidase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length564
- Mass (Da)62,501
- Last updated2013-05-01 v1
- Checksum88E8FCCB0FE38267