M3D6M7 · M3D6M7_9ACTN

Function

function

Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT.

Catalytic activity

  • ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.
    EC:2.7.13.3 (UniProtKB | ENZYME | Rhea)

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentmembrane
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functionphosphorelay sensor kinase activity
Molecular Functionprotein dimerization activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Oxygen sensor histidine kinase NreB
  • EC number
  • Alternative names
    • Nitrogen regulation protein B

Gene names

    • ORF names
      SBD_6379

Organism names

Accessions

  • Primary accession
    M3D6M7

Proteomes

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane55-76Helical
Transmembrane83-101Helical
Transmembrane130-147Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain204-403Histidine kinase

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    413
  • Mass (Da)
    44,248
  • Last updated
    2013-05-01 v1
  • Checksum
    646DBFA782BFC0A5
MPVRTVVEGIAAVPAIAAPAVPHRGPLPVRRLPDLLFLTVVVGGVVRLVDLNSALCWELVPLIVLLAAGYVAGPALRDRLGRWGRPVWFGALLALWCLVSWEMPTPAATAYTWLALPLAILALRMFTGPAALAVVGVLTVPLVVLIARTTGTVHPEQLLPPTAALWATVALYRAQQRLLGELRSTRAELARGQREAGRLAERARIARDLHDTLAQELAGSRMLLQAADRDWDRRPDLARAQVRTVVDALDTNLAETRTIISDLTPPALEHDDLSTALRTLCTRTTATPSRVVFRTEGEPGDLPHDRAAALLRVAQGLLANACEHARAQHVWVTLDHRDDTTVTVEVRDDGVGFDTRATTAKRCDRGLGLTGGRERLGALGGSLTVRSAPGRGTLARASLPMGSLALAGPAGDR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KB405095
EMBL· GenBank· DDBJ
EMF51857.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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