M2XXT9 · M2XXT9_GALSU

  • Protein
    Trifunctional protein carbamoyl-phosphate synthase (Glutamine-dependent) / aspartate carbamoyltransferase / dihydroorotase (CAD protein)
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    5/5

Function

Catalytic activity

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.
Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site670Nucleophile
Active site755
Active site757

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionamino acid binding
Molecular Functionaspartate carbamoyltransferase activity
Molecular FunctionATP binding
Molecular Functioncarbamoyl-phosphate synthase (ammonia) activity
Molecular Functioncarbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Molecular Functionclass I DNA-(apurinic or apyrimidinic site) endonuclease activity
Molecular Functiondamaged DNA binding
Molecular Functiondihydroorotase activity
Molecular Functionglutaminase activity
Molecular Functionmetal ion binding
Molecular Functionoxidized purine nucleobase lesion DNA N-glycosylase activity
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological Process'de novo' UMP biosynthetic process
Biological Processbase-excision repair
Biological Processcitrulline biosynthetic process
Biological Processglutamine metabolic process
Biological Processnucleotide-excision repair
Biological ProcessUTP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Submitted names
    • Trifunctional protein carbamoyl-phosphate synthase (Glutamine-dependent) / aspartate carbamoyltransferase / dihydroorotase (CAD protein)
      (EC:2.1.3.2
      , EC:3.5.2.3
      , EC:6.3.5.5
      )

Gene names

    • ORF names
      Gasu_42540

Organism names

Accessions

  • Primary accession
    M2XXT9

Proteomes

Genome annotation databases

Subcellular Location

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain940-1132ATP-grasp
Domain1487-1678ATP-grasp
Domain1744-1900MGS-like
Region2201-2231Disordered

Sequence similarities

In the 2nd section; belongs to the CarB family.
In the 3rd section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily.
In the C-terminal section; belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
In the N-terminal section; belongs to the CarA family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    2,626
  • Mass (Da)
    294,785
  • Last updated
    2013-05-01 v1
  • Checksum
    375DB47051C5FD23
MELQSKVRKFSKRQRLCGKASSLWYPLNNPPKELSLSRTLPCGQSFLWKRYGKEKDNQEYWLGVVDDTIVQLYQPNTLGPVYFQPVHCLSESISIEHLRKRLVEFFNLHISYSSLLEQFCKVDPRFEKVVEYTQGARVLSLDPFECLCGYLCSSNNNIQRISKMMQFIAQHGNYIGQVEQHKFYCFPTLNQMRSVTEQDLRSHRFGYRAKYLVHTIDRLVQLGGIEWLSELKQLDREQVVSQLMQLPGIGHKVASCIALVSLGKHDEIPVDTHIWQVVLKYYLPQLHGKTLTQRVHREIGEWFRQKFGAYAGWAHNTLFLVEIVMKLNMKTLLIEYLFVNGAKKLAFFIVGKYQLISNSLGGEEDCHLFLGSVVFLLYNLVSLLEQENERIQGKWIDRDAYSCQAYFGRRQVAHSVGTVFHGYSFGAKRSSSGEAVFQTGMVGYPEALTDPSYRGQILCFTYPLIGNYGVPSEKEVDHNGIPLYFESYEIHTAGVVVSSFTEKHSHWKAESSFDSWLKRNNVSGIYDIDTRQLTQIIREKGTMLAKIVVDSELSFYDLNQTNLVAQVSIKEPIIYRPPLGNTLCHILMVDCGIKYNQIRCFLNRQAQITLVPWDYDFSSPETLQNIDGIFLSNGPGDPSMCEITIHHIKNILEAAEKRDSSRVTPMFGICLGHQLLSLAAGFETFKMKYGNRGHNVPCLELTSGHCYITSQNHGYAVDTSSKKIPHWQPLYVNLNDQTNEGICNDRFPFFSVQFHPEASAGPHDTEFLFDLFLDIVQTNKSTQSASNYVSAWDIFLNYKKPKIPKSIEEDGRHIRKVLLLGSGGLSIGQAGEFDYSGTQALKALKEEGIKTVLVNPNIATVQTSRGMADKVYFLPINPESVAKVIRNERPDGILVTFGGQTALNCGIKLHQSGIFEEYGVSVLGTPIETILDTEDRERFNLRLSEIGEPFAHSIACSSLDATLKAAKEIGYPVILRAAFALGGLGSGFANDAEELTNLASRAFSTSDQVLIEKSMKGWKEIEYEVVRDAYDHCITVCNMENFDPLGIHTGESIVVAPSQTLDDYEYHMLRDSAMKTIRHLGVVGECNIQFALNPNSRQYCIIEVNARLSRSSALASKATGYPLAFVAAKLALGIPLTQIRNSITQSTTACFEPSLDYIVVKMPRWDLKKFTRVSKLLGSSMKSVGEVMAIGRNFCEAIQKAIRCVKENYVFGLDSSVVPYTTEEMSNPTDERIFAIANGLANGMTVDKIHQLTHIDRWFLNHLESIILLEKHLQKVASNGQSLQELDLWYAKSLGMSDKHIAKCIGETELVIRSLRMQLQVKPLVKRIDTVAAEFPAVTNYLYTTYVNGRGYNLSKEMQKNDVAFDREGIMVLGSGAYRIGSSVEFDWCAVSAVRTLRNQHIYSVMVNHNPETVSTDYDECDRLYFEELSLERVLDIYELEKATGVIVSMGGQIPNNIAMQLHRQHARILGTTPEMIDGAENRYKFSRMLDRLQVDQPEWKELTSLEDAKAFCLKVGYPCLVRPSYVLSGAAMNVAHKPEDLESYLTEAAKVSLDSPVVISKFILEAKEIEVDAVANKGELIMHVITEHVENAGVHSGDATLILPPQDLDEITVRKVEEATMKVANALNVTGPMNIQFIAKNNEIKVIECNLRASRSFPFVSKTLGIDLAKMATKIMIGKSVKPYPVHVNSVQLVGVKVPQFSFTRLLGADPILGVEMASTGEVACYGATREEAYLKGYLATGQRLPKRNICLSIGPYKEKLEFLSCANKLVEMGFHLFSTPGTAEFLSEHGIPSTVVIWPKNEEYARDVERNILEVLKEKAIDLFINLPSNNQYRRLASFLSPGYLSRRAAVDFSVPLITNVKCAKLFVNALYTLGGRNVYLPLQPYDARFSSRVITLSGFISFNTAIDENQSISSIMEQGLEGGFTTICLHATRGLYDSQDLDSLKSQIDSNFYGIATNYTIYVDAHRDNIHTISCLFKSSAGLYLKISDSSFWWWKHLENWPNNSPILVEATGLVLASILFGSVIHGSRPLHITQVCKKEDMEIIRAAKNKGMAITCDVSIVHLYGNNMDASDREALWENLDIIDVVCGPLNQTISLLLASVQEGRLGISWVESRLVDNPRRILGLSPSIGTFVEVNLDTCWTEQNSSSPFYGQMCRGVVQRTVIHNEIVYLDGKMLCKGQRIGKDVRIQDKASSENIHPSVGLSTSYPMKERRGAASVPPLDREDNLTPLIGKEKHLPTETTDSIPLNSQTQSSTYIYSPTAQKPSFTIQDEKWDLSYSSSMPKTQPSWKTTFPSSLMPTRNVDAIETLNGYGNGWLAGNHILSVAQFTRQQLHALFNVAYEMRQMVQRVGYYDLLKGKVMATLFYEPSTRTCSSFAAAMQRLGGSVLPIQEMSHSSVAKGESLSDTVRTVSCYSDIIVIRHFEKGAAQTAASVAGKPVINAGDGIGEHPTQALLDIFTIREELGTVNGLTITFVGDLKNGRTVHSLALLLCLYHVRIRYVSPESLRMPEDVLEKIASKGIDQREYHDLQQIISETDVLYVTRIQKERFSSPQEYEKCQQGYIITPKLLTRAKEHMIVMHPLPRVQEISTQVDQDPRAVYFRQMEYGMYVRMALLAMILGKA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KB454522
EMBL· GenBank· DDBJ
EME28254.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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