M2URK9 · OBLC_COCH5

Function

function

FAD-dependent oxidoreductase; part of the gene cluster that mediates the biosynthesis of the sesterterpenes ophiobolins, fungal phytotoxins with potential anti-cancer activities (PubMed:27116000).
The first step of the pathway is performed by the sesterterpene synthase oblA that possesses both prenyl transferase and terpene cyclase activity, converting isopentenyl diphosphate and dimethylallyl diphosphate into geranylfarnesyl diphosphate (GFPP) and further converting GFPP into ophiobolin F, respectively (By similarity).
Other sesterterpenoids (C25 terpenoids) are found as minor products of oblA (By similarity).
The cytochrome P450 monooxygenase oblB then catalyzes a four-step oxidative transformation of ophiobolin F to yield ophiobolin C (PubMed:27116000).
The FAD-dependent oxidoreductase oblC might be involved in a later oxidation step that produces ophiobolin A (Probable)

Cofactor

FAD (UniProtKB | Rhea| CHEBI:57692 )

Pathway

Secondary metabolite biosynthesis; terpenoid biosynthesis.

GO annotations

AspectTerm
Molecular Functionoxidoreductase activity
Biological Processterpenoid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    FAD-dependent oxidoreductase oblC
  • EC number
  • Alternative names
    • Ophiobolin biosynthesis cluster protein C

Gene names

    • Name
      oblC
    • ORF names
      COCHEDRAFT_1167272

Organism names

Accessions

  • Primary accession
    M2URK9

Proteomes

PTM/Processing

Features

Showing features for signal, chain, glycosylation.

TypeIDPosition(s)Description
Signal1-21
ChainPRO_500402786222-483FAD-dependent oxidoreductase oblC
Glycosylation100N-linked (GlcNAc...) asparagine
Glycosylation137N-linked (GlcNAc...) asparagine
Glycosylation190N-linked (GlcNAc...) asparagine
Glycosylation240N-linked (GlcNAc...) asparagine

Keywords

PTM databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    483
  • Mass (Da)
    52,924
  • Last updated
    2013-05-01 v1
  • Checksum
    307C83AFD19F2CC9
MRSVTSLVSFSACLLASSVTAADTPLTVNGKKFYSQDIITRDVVVVGGGSSGCHIAVRLQDAGKSVVVVEKSARLGGHVATYTDPATRKTAEQGLVTFHNTTHVTDYLTRLDIPLAPISFSPSTNFDYDLRTGKPVNRTYNPTQEEFAAGFAGYSAQLAKYPQLNDGTFLPYPVPEDLTMPFGKFLEKYNLTGALMQMYNFNWGTGNFLTNPTVEQMRYWGANTVAAVTTGKFLVTARHNSSEIYTKVGNVLGATSSVLLNSEVTYTRRSEGKTGVQLIVKTPEGSKLLVAKKLVIAIPPKLDFVAPLDLSKTEKDLFGKYIDAGYYVGMVRNTGIPARTLITNSAQDTPYNLPVLPAVNIMNPTAIDGVWTVFSSSLQSKASFPWADDAVKADIIRSIKALQTANPDKFQQTEPEIIEWHSHAPYFLQVSSEEIKNGFYAKLYALQGLRNTHFTGAAWRVHDSSQIWKYTDTQVLPKLLAGL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KB445570
EMBL· GenBank· DDBJ
EMD96236.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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