M2URK9 · OBLC_COCH5
- ProteinFAD-dependent oxidoreductase oblC
- GeneoblC
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids483 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
FAD-dependent oxidoreductase; part of the gene cluster that mediates the biosynthesis of the sesterterpenes ophiobolins, fungal phytotoxins with potential anti-cancer activities (PubMed:27116000).
The first step of the pathway is performed by the sesterterpene synthase oblA that possesses both prenyl transferase and terpene cyclase activity, converting isopentenyl diphosphate and dimethylallyl diphosphate into geranylfarnesyl diphosphate (GFPP) and further converting GFPP into ophiobolin F, respectively (By similarity).
Other sesterterpenoids (C25 terpenoids) are found as minor products of oblA (By similarity).
The cytochrome P450 monooxygenase oblB then catalyzes a four-step oxidative transformation of ophiobolin F to yield ophiobolin C (PubMed:27116000).
The FAD-dependent oxidoreductase oblC might be involved in a later oxidation step that produces ophiobolin A (Probable)
The first step of the pathway is performed by the sesterterpene synthase oblA that possesses both prenyl transferase and terpene cyclase activity, converting isopentenyl diphosphate and dimethylallyl diphosphate into geranylfarnesyl diphosphate (GFPP) and further converting GFPP into ophiobolin F, respectively (By similarity).
Other sesterterpenoids (C25 terpenoids) are found as minor products of oblA (By similarity).
The cytochrome P450 monooxygenase oblB then catalyzes a four-step oxidative transformation of ophiobolin F to yield ophiobolin C (PubMed:27116000).
The FAD-dependent oxidoreductase oblC might be involved in a later oxidation step that produces ophiobolin A (Probable)
Cofactor
Pathway
Secondary metabolite biosynthesis; terpenoid biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | oxidoreductase activity | |
Biological Process | terpenoid biosynthetic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameFAD-dependent oxidoreductase oblC
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Dothideomycetes > Pleosporomycetidae > Pleosporales > Pleosporineae > Pleosporaceae > Bipolaris
Accessions
- Primary accessionM2URK9
Proteomes
PTM/Processing
Features
Showing features for signal, chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-21 | |||||
Sequence: MRSVTSLVSFSACLLASSVTA | ||||||
Chain | PRO_5004027862 | 22-483 | FAD-dependent oxidoreductase oblC | |||
Sequence: ADTPLTVNGKKFYSQDIITRDVVVVGGGSSGCHIAVRLQDAGKSVVVVEKSARLGGHVATYTDPATRKTAEQGLVTFHNTTHVTDYLTRLDIPLAPISFSPSTNFDYDLRTGKPVNRTYNPTQEEFAAGFAGYSAQLAKYPQLNDGTFLPYPVPEDLTMPFGKFLEKYNLTGALMQMYNFNWGTGNFLTNPTVEQMRYWGANTVAAVTTGKFLVTARHNSSEIYTKVGNVLGATSSVLLNSEVTYTRRSEGKTGVQLIVKTPEGSKLLVAKKLVIAIPPKLDFVAPLDLSKTEKDLFGKYIDAGYYVGMVRNTGIPARTLITNSAQDTPYNLPVLPAVNIMNPTAIDGVWTVFSSSLQSKASFPWADDAVKADIIRSIKALQTANPDKFQQTEPEIIEWHSHAPYFLQVSSEEIKNGFYAKLYALQGLRNTHFTGAAWRVHDSSQIWKYTDTQVLPKLLAGL | ||||||
Glycosylation | 100 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 137 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 190 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 240 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
PTM databases
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length483
- Mass (Da)52,924
- Last updated2013-05-01 v1
- Checksum307C83AFD19F2CC9
Keywords
- Technical term