M2SNN6 · LAEA_COCH5

Function

function

Methyltransferase that performs automethylation (By similarity).
No other methyl-accepting substrate has been identified yet (By similarity).
Component of the velvet transcription factor complex that acts as a global regulator for secondary metabolite gene expression (By similarity).
Controls the expression of the T-toxin gene cluster (PubMed:22383877).
Promotes oxidative stress tolerance and acts as a virulence factors during infection (PubMed:22383877).
Negatively regulate mycelial pigmentation and controls sexual development, as well as asexual development during vegetative growth (PubMed:22383877).

Catalytic activity

GO annotations

AspectTerm
Cellular Componentnucleus
Molecular Functionmethyltransferase activity
Biological Processmethylation
Biological Processsporulation resulting in formation of a cellular spore

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Secondary metabolism regulator LAE1
  • Alternative names
    • Methyltransferase LAE1
      (EC:2.1.1.-
      ) . EC:2.1.1.- (UniProtKB | ENZYME | Rhea)
    • Velvet complex subunit LAE1

Gene names

    • Name
      LAE1
    • ORF names
      COCHEDRAFT_1197809

Organism names

Accessions

  • Primary accession
    M2SNN6
  • Secondary accessions
    • G4XKY9

Proteomes

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

Leads to hypersensitivity to oxidative stress, compromised reproductive development, repression of asexual sporulation, and reduction of virulence during maize infection (PubMed:22383877).

Miscellaneous

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004357481-307Secondary metabolism regulator LAE1

Interaction

Subunit

Component of the heterotrimeric velvet complex composed of LAE1, VEL1 and VEL2; VEL1 acting as a bridging protein between LAE1 and VEL2 (By similarity).

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    307
  • Mass (Da)
    36,056
  • Last updated
    2013-05-01 v1
  • Checksum
    BD0188BF582D9870
MTSNGLPVPAQNSNYMENGRWYHGFRRGLYMYPCDEPEKDRMDIYHQFFAVARRGQLHQAPVPSEPHLQPRILDVGCGTGIWAIDMADKYLNAEVLGLDLVNIQPEKIPPNLRFRVPRDYESPWTLGEDSWDLIHLRMACGSVESWPELYQKIYTHLKPGTGWIEHIEIDMEPRCDDYTLPPDSMLRKWYGWLADATQRAYRPIAYEHRTRQLLQAAGFIDIQETVIRVPYNTWPNDPHQKDIGRWYNLGLTEGLEALTFAPLTRVYHWDLNAHVRPIVEGVRRELCNRKIHAYNNIHIWTARRPQQ

Sequence caution

The sequence AEP40318.1 differs from that shown. Reason: Erroneous gene model prediction

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JF826792
EMBL· GenBank· DDBJ
AEP40318.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
KB445583
EMBL· GenBank· DDBJ
EMD86920.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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