M2QX87 · M2QX87_CERS8
- ProteinSaccharopine dehydrogenase [NAD(+), L-lysine-forming]
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids368 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
Catalytic activity
- L-saccharopine + NAD+ + H2O = L-lysine + 2-oxoglutarate + NADH + H+
Pathway
Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 3/3.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 77 | Proton acceptor | |||
Active site | 95 | Proton donor | |||
Binding site | 129 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 195-196 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 219 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 223 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 243 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 272 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 313-316 | NAD+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | saccharopine dehydrogenase (NAD+, L-lysine-forming) activity | |
Biological Process | lysine biosynthetic process via aminoadipic acid |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSaccharopine dehydrogenase [NAD(+), L-lysine-forming]
- EC number
- Short namesSDH
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Basidiomycota > Agaricomycotina > Agaricomycetes > Polyporales > Gelatoporiaceae > Gelatoporia
Accessions
- Primary accessionM2QX87
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for disulfide bond.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Disulfide bond | 197↔241 | ||||
Keywords
- PTM
Interaction
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 7-141 | Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal | |||
Domain | 171-312 | Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding | |||
Sequence similarities
Belongs to the AlaDH/PNT family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length368
- Mass (Da)40,279
- Last updated2013-05-01 v1
- MD5 Checksum6182CDF8BC0E96DCE5C712834A0C249E
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KB445791 EMBL· GenBank· DDBJ | EMD41743.1 EMBL· GenBank· DDBJ | Genomic DNA |