M0R4C3 · M0R4C3_RAT
- ProteinMitogen-activated protein kinase
- GeneMapk7
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids772 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H+
Cofactor
Activity regulation
Activated by threonine and tyrosine phosphorylation.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 85 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | MAP kinase activity | |
Biological Process | protein phosphorylation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMitogen-activated protein kinase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionM0R4C3
Proteomes
Organism-specific databases
Subcellular Location
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 1-18 | Basic and acidic residues | |||
Region | 1-24 | Disordered | |||
Domain | 55-347 | Protein kinase | |||
Region | 424-475 | Disordered | |||
Region | 488-731 | Disordered | |||
Compositional bias | 506-545 | Basic and acidic residues | |||
Compositional bias | 578-604 | Pro residues | |||
Compositional bias | 605-621 | Polar residues | |||
Compositional bias | 628-650 | Pro residues | |||
Compositional bias | 651-669 | Polar residues | |||
Compositional bias | 681-697 | Pro residues | |||
Compositional bias | 698-718 | Polar residues | |||
Sequence similarities
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length772
- Mass (Da)84,144
- Last updated2022-05-25 v1
- Checksum96FDE89F3D3AA555
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 1-18 | Basic and acidic residues | |||
Compositional bias | 506-545 | Basic and acidic residues | |||
Compositional bias | 578-604 | Pro residues | |||
Compositional bias | 605-621 | Polar residues | |||
Compositional bias | 628-650 | Pro residues | |||
Compositional bias | 651-669 | Polar residues | |||
Compositional bias | 681-697 | Pro residues | |||
Compositional bias | 698-718 | Polar residues | |||
Keywords
- Technical term