M0LT15 · M0LT15_9EURY

Function

function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

One-carbon metabolism; tetrahydrofolate interconversion.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site164-166NADP+ (UniProtKB | ChEBI)
Binding site234NADP+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionmethenyltetrahydrofolate cyclohydrolase activity
Molecular Functionmethylenetetrahydrofolate dehydrogenase (NADP+) activity
Biological ProcessL-histidine biosynthetic process
Biological Processmethionine biosynthetic process
Biological Processpurine nucleotide biosynthetic process
Biological Processtetrahydrofolate interconversion

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Bifunctional protein FolD

Including 2 domains:

  • Recommended name
    Methylenetetrahydrofolate dehydrogenase
  • EC number
  • Recommended name
    Methenyltetrahydrofolate cyclohydrolase
  • EC number

Gene names

    • Name
      folD
    • ORF names
      C447_17127

Organism names

  • Taxonomic identifier
  • Strain
    • 100A6
  • Taxonomic lineage
    Archaea > Euryarchaeota > Stenosarchaea group > Halobacteria > Halobacteriales > Halococcaceae > Halococcus

Accessions

  • Primary accession
    M0LT15

Proteomes

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain5-119Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Domain122-289Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding

Sequence similarities

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    297
  • Mass (Da)
    31,430
  • Last updated
    2013-04-03 v1
  • Checksum
    BEE4A32E9EF24F8E
MTDVIDGNAVADDIRSSLEDCIATFEDAGVTPGLATVLVGDDPASETYVSMKQRDCEEVGINGVHVELPADASQDDLNSTIDELNDDPEVHGYLVQDPTPDQIDYREVIRRIDPAKDVDGFHPENVGRLVAGDARFKPCTPHGVQKLLASANVDTEGKDITIVGRSRIVGKPLANLLLQKADDGNATVTVCHSRTQDLAEKTRNADVVVAAVGAPELVDGSMIGEGAVVIDVGVNRVDADTEKGYELVGDVEFESAKEQASAITPVPGGVGPMTRAMLLYNTVKAASEQEGVDVDLP

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AOMB01000044
EMBL· GenBank· DDBJ
EMA35514.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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