M0LRK4 · M0LRK4_9EURY

Function

function

Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 2 Mg2+ ions per subunit.

Pathway

Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site33-35ATP (UniProtKB | ChEBI)
Binding site89-90ATP (UniProtKB | ChEBI)
Binding site122Mg2+ 1 (UniProtKB | ChEBI)
Binding site159Mg2+ 2 (UniProtKB | ChEBI)
Active site183
Binding site185D-ribose 5-phosphate (UniProtKB | ChEBI)
Binding site209D-ribose 5-phosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionkinase activity
Molecular Functionmagnesium ion binding
Molecular Functionribose phosphate diphosphokinase activity
Biological Process5-phosphoribose 1-diphosphate biosynthetic process
Biological Processnucleotide biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ribose-phosphate pyrophosphokinase
  • EC number
  • Short names
    RPPK
  • Alternative names
    • 5-phospho-D-ribosyl alpha-1-diphosphate synthase
    • Phosphoribosyl diphosphate synthase
    • Phosphoribosyl pyrophosphate synthase
      (P-Rib-PP synthase
      ; PRPP synthase
      ; PRPPase
      )

Gene names

    • Name
      prs
    • ORF names
      C447_15656

Organism names

  • Taxonomic identifier
  • Strain
    • 100A6
  • Taxonomic lineage
    Archaea > Euryarchaeota > Stenosarchaea group > Halobacteria > Halobacteriales > Halococcaceae > Halococcus

Accessions

  • Primary accession
    M0LRK4

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-111Ribose-phosphate pyrophosphokinase N-terminal
Domain151-240Phosphoribosyltransferase

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    283
  • Mass (Da)
    29,412
  • Last updated
    2013-04-03 v1
  • Checksum
    2BAAD4B036CE1711
MIVSASTSQSLASALAAETGEPLAATAVERFPDGEFQVSVPDFDAQRAVVVCATTTADAHLEALQLQDAVREAGAEEVVTVIPYLGYARQDKAFEPGQPVSVRAIARALSTGTDRVVTVTPHEESVREFFDVPCTTVDAAGVLADPLPDLHDPVFVAPDAGATDLAATVQDAYGEGAVDHFEKTRHSSTEVELEPHESAIADRDVVLVDDIIATGSTMAGAVAHLQEGGVGRVFVTCVHPVLAGTARLRLARAGVEAVYGTDTVERAETTVSVAPALADALDG

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AOMB01000042
EMBL· GenBank· DDBJ
EMA36222.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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