M0FQI9 · M0FQI9_9EURY

Function

function

Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit. The magnesium is bound as Mg-PRPP.

Activity regulation

Allosterically activated by GTP.

Pathway

Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site36-40GTP (UniProtKB | ChEBI)
Binding site865-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site1115-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site145-1535-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site211uracil (UniProtKB | ChEBI)
Binding site216-218uracil (UniProtKB | ChEBI)
Binding site2175-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular FunctionGTP binding
Molecular Functionmagnesium ion binding
Molecular Functionuracil phosphoribosyltransferase activity
Biological ProcessUMP salvage
Biological Processuracil salvage

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Uracil phosphoribosyltransferase
  • EC number
  • Alternative names
    • UMP pyrophosphorylase
    • UPRTase

Gene names

    • Name
      upp
    • ORF names
      C459_14015

Organism names

  • Taxonomic identifier
  • Strain
    • ATCC BAA-645
  • Taxonomic lineage
    Archaea > Euryarchaeota > Stenosarchaea group > Halobacteria > Halobacteriales > Haloferacaceae > Haloferax

Accessions

  • Primary accession
    M0FQI9

Proteomes

Family & Domains

Sequence similarities

Belongs to the UPRTase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    226
  • Mass (Da)
    24,502
  • Last updated
    2013-04-03 v1
  • Checksum
    D235D0BB0635E4F2
MPIEDRDDAYLITHALAKDTLSRLRDVETTQVAFRKGLVKLGRICGYEIIDGAMETEYVTIQTPLAETTGERVKGLDNVVIINVLRAATPFVEGLLKAFPRAKQGVISAGRDEEAGMDDDGGFPITIDYVKLPEITEKDTVIVADPMLATGSTMCSVLDHILENAGVDPEKLFVLSAVSAPDGLLRVDNEFPEVDLLTVAIDDYLDDDGYIVPGLGDAGDRAFRTT

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AOLE01000026
EMBL· GenBank· DDBJ
ELZ62321.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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