M0FKV8 · M0FKV8_9EURY

  • Protein
    3-isopropylmalate dehydratase large subunit
  • Gene
    leuC
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster per subunit.

Pathway

Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site303[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site363[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site366[4Fe-4S] cluster (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function3-isopropylmalate dehydratase activity
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functionmetal ion binding
Biological ProcessL-leucine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    3-isopropylmalate dehydratase large subunit
  • EC number
  • Alternative names
    • Alpha-IPM isomerase
      (IPMI
      )
    • Isopropylmalate isomerase

Gene names

    • Name
      leuC
    • ORF names
      C459_17546

Organism names

  • Taxonomic identifier
  • Strain
    • ATCC BAA-645
  • Taxonomic lineage
    Archaea > Euryarchaeota > Stenosarchaea group > Halobacteria > Halobacteriales > Haloferacaceae > Haloferax

Accessions

  • Primary accession
    M0FKV8

Proteomes

Interaction

Subunit

Heterodimer of LeuC and LeuD.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain22-290Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Domain290-414Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha

Sequence similarities

Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    437
  • Mass (Da)
    45,953
  • Last updated
    2013-04-03 v1
  • Checksum
    534B27B9BBA931CA
MSGKTLAEKLLSEKSGTDARAGDYVEADVDVAMAHDITGPLAFRTFDEVTGDDGELFAPDRTVFTIDHHAPADGVQAANNHNAVREFAAEHGAHQFDVGDGICHAVLVEEGFVGPGDLVIGADSHSTTYGGIGAFGTGVGSTDLGTALATGELWFRVPKTLRFEVDGDLGDGVYAKDLILRFIGDVGFDGCTYMAAEYAGSTIESLPIHERLVLSNMAIEMGGKAGLVAPDERTESYLERQTGNEIDLGDAFVSDDDADYEAVHTYDAADLAPQVSKPSNPENAVDVTEVAGTELDQLFVGTCTNGRYEDIKIVADILAGETIAPNVRMVVVPASKSVYQHMLGTGVFQTLTDAGAVIQSAGCGPCAGYHQGVLGDGDVCLATANRNFPGREGSMESSVYLSSPATVGASALYGEITDPREVETNRYDDTVFAEVLS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AOLE01000037
EMBL· GenBank· DDBJ
ELZ60545.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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