M0ERN8 · M0ERN8_9EURY

  • Protein
    Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    5/5

Function

function

Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t6A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Fe2+ (UniProtKB | Rhea| CHEBI:29033 )

Note: Binds 1 Fe2+ ion per subunit.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site110Fe cation (UniProtKB | ChEBI)
Binding site114Fe cation (UniProtKB | ChEBI)
Binding site131-135L-threonylcarbamoyladenylate (UniProtKB | ChEBI)
Binding site163L-threonylcarbamoyladenylate (UniProtKB | ChEBI)
Binding site176L-threonylcarbamoyladenylate (UniProtKB | ChEBI)
Binding site180L-threonylcarbamoyladenylate (UniProtKB | ChEBI)
Binding site273L-threonylcarbamoyladenylate (UniProtKB | ChEBI)
Binding site301Fe cation (UniProtKB | ChEBI)
Binding site365-373ATP (UniProtKB | ChEBI)
Binding site386ATP (UniProtKB | ChEBI)
Active site475Proton acceptor; for kinase activity

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular ComponentEKC/KEOPS complex
Molecular Function3-phosphoinositide-dependent protein kinase activity
Molecular FunctionAMP-activated protein kinase activity
Molecular FunctionATP binding
Molecular FunctionDNA-dependent protein kinase activity
Molecular Functionhistone H2AS1 kinase activity
Molecular Functionhistone H2AS121 kinase activity
Molecular Functionhistone H2AT120 kinase activity
Molecular Functionhistone H2AXS139 kinase activity
Molecular Functionhistone H2BS14 kinase activity
Molecular Functionhistone H2BS36 kinase activity
Molecular Functionhistone H3S10 kinase activity
Molecular Functionhistone H3S28 kinase activity
Molecular Functionhistone H3S57 kinase activity
Molecular Functionhistone H3T11 kinase activity
Molecular Functionhistone H3T3 kinase activity
Molecular Functionhistone H3T45 kinase activity
Molecular Functionhistone H3T6 kinase activity
Molecular Functionhistone H4S1 kinase activity
Molecular Functioniron ion binding
Molecular Functionmetalloendopeptidase activity
Molecular FunctionN(6)-L-threonylcarbamoyladenine synthase activity
Molecular Functionprotein serine kinase activity
Molecular Functionprotein serine/threonine/tyrosine kinase activity
Molecular FunctionRho-dependent protein serine/threonine kinase activity
Molecular Functionribosomal protein S6 kinase activity
Molecular Functionzinc ion binding
Biological ProcesstRNA threonylcarbamoyladenosine modification

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein

Including 2 domains:

  • Recommended name
    tRNA N6-adenosine threonylcarbamoyltransferase
  • EC number
  • Alternative names
    • tRNA threonylcarbamoyladenosine biosynthesis protein Kae1
    • t(6)A37 threonylcarbamoyladenosine biosynthesis protein Kae1
  • Recommended name
    Serine/threonine-protein kinase Bud32
  • EC number

Gene names

    • ORF names
      C465_08226

Organism names

  • Taxonomic identifier
  • Strain
    • JCM 9100
  • Taxonomic lineage
    Archaea > Methanobacteriati > Methanobacteriota > Stenosarchaea group > Halobacteria > Halobacteriales > Haloferacaceae > Halorubrum > Halorubrum distributum group

Accessions

  • Primary accession
    M0ERN8

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.

Family & Domains

Features

Showing features for region, domain, compositional bias.

Type
IDPosition(s)Description
Region1-340Kae1
Domain27-307Gcp-like
Region345-371Disordered
Compositional bias360-369Basic and acidic residues
Region476-499Disordered

Sequence similarities

In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.
In the N-terminal section; belongs to the KAE1 / TsaD family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    571
  • Mass (Da)
    60,123
  • Last updated
    2013-04-03 v1
  • MD5 Checksum
    38B26DCEF6ED1052C0A0415392D568DA
MRVLGIEGTAWCASAALYDAETDSVLIESDAYEPDSGGIHPREAAEHMSEAIPEVVDHMLAVAEDEHGPDAIDAVAFSRGPGLGPCLRIVGTAARSLAGTLDVPLVGVNHMVAHLEIGRHRSGFDNPVCLNASGANAHLLGYHDGRYRVLGETMDAGVGNAIDKFTRHVGWSHPGGPKVEAAAAEFAGTDPGADGGDSTANLLDLPYVVKGMDFSFSGISSAANDAADDGVPVGEICFSLQEHAFAMLTEVSERALSLTGADELVLGGGVAQNDRLREMLAAMCEARGADFHAPEPRFLRDNAGMIAVLGAKMAAAGDTVAISESAVDPNFRPDQVPVTWRDGESVARGGGGGAAGGAARDPDADRRGAEATVTVAGSGEDRRVIKRRVPKSYRHPDLDRTLRRDRTVAEARLTSEARRAGVPTPLVDDVDLASATLTLQYVGDRDLAAALDERWTEAVGRHLARLHGAGIVHGDPTTRNVRVSPDGVGRRRGNGESDAPPEAYLIDFGLGYHTGHVEDHAMDLHVFEGSIRATATDPDPLIAAFEAGYGAAGDDEVLERLRDVADRGRYR

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias360-369Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AOJM01000046
EMBL· GenBank· DDBJ
ELZ49542.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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