L9ZES0 · FSX1_NATA2

Function

function

Exhibits fusogenic activity (PubMed:35794124).
Mediates cell-cell fusion in mammalian cells (bilateral fusion) (PubMed:35794124).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcell surface
Cellular Componentplasma membrane
Molecular Functionmetal ion binding
Biological Processplasma membrane fusion

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Fusexin 1
  • Short names
    NaFsx1

Gene names

    • Name
      fsx1
    • ORF names
      C485_18087

Organism names

Accessions

  • Primary accession
    L9ZES0

Proteomes

Subcellular Location

Cell surface
Cell membrane
; Multi-pass membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-12Cytoplasmic
Transmembrane13-33Helical
Topological domain34-574Extracellular
Transmembrane575-595Helical
Topological domain596-628Cytoplasmic
Transmembrane629-649Helical
Topological domain650Extracellular
Transmembrane651-671Helical

Keywords

PTM/Processing

Features

Showing features for chain, disulfide bond.

TypeIDPosition(s)Description
ChainPRO_00004580061-671Fusexin 1
Disulfide bond145↔180
Disulfide bond409↔452
Disulfide bond480↔500
Disulfide bond513↔528

Keywords

Interaction

Subunit

Homotrimer stabilized by interdomain contacts and numerous Ca2+ and Na+ ions.

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region168-173Fusion loop

Domain

The extracellular N-terminus has 4 domains; the first 3 are structurally similar to fusogens from plants, C.elegans and viruses, while the fourth domain is unique to archaea. Domains I and II are discontinuous. The fusion loop in domain II is stabilized by a Ca2+ ion so that it protrudes from the molecule.

Sequence similarities

Belongs to the HAP2/GCS1 family. Fusexin 1 subfamily.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    671
  • Mass (Da)
    73,338
  • Last updated
    2013-04-03 v1
  • Checksum
    F39C0460D2E5D2EA
MRAVSDFLKNKWVAVPAVALLILSLGFLAQNYITGSFVSGDQIEYTSNSEFFDGEVFVINYIGDRTTDKIHAEIPASELASAADGEVTKELTIDITSQETYARYSTTSTSLSRIYAFKAINSEVFTDTSSSEVESRKQSWAEQNCYDIDGDSEIEQGDDYTQRFWVDGAIADYYNAQVYCVRENGYYGNIAELSSPDKEFEAEVEVKADGETPQSTTLSNSDLGQGRCDNIGEYVRACWTGLNPTGEGVPEPYNVYAIHSNTFSPEWRVISAERYSSYNSYVENNLYSQIEAWKEGSLSQEEVVSTANDQAAQAAQRVSSGSFTDYQVEDSSYENGQIRLNPSYDIAWPEFTFYVDGADYISVEKPVGEPRIVNVEGDEFGEKQSGTVTAEVENTASYEGSFSARVSKCSDSFGYDSLQETKTVGPGETVSFDFRVSFTSDSFDQKTVSGSCEIVVSDTGDSSNSDTAVVDVEATQSNECTPNEEFVRTINSTHSRILECSSDGLTTTEVDVCGDGEEAAFRDSSWTCVSDGTLPGGGDGSGGSGGGGDTDDCVVFAVGDLEIEDPFCADGPLEMLSKMFHLVAGTAVAFFTGSLGYRAGRWVDGEYQIKGGFDPLKSRSVSRAKRGRFLIGLIAELVSFLLGFYVILLVPIWAQLMVILGYVLFKYYTPF

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AOIK01000043
EMBL· GenBank· DDBJ
ELY83688.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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