L9LBF6 · L9LBF6_TUPCH

Function

function

Acts as an acyl-protein thioesterase. Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Acts as a palmitoyl thioesterase that catalyzes depalmitoylation of proteins, such as ADRB2, KCNMA1 and SQSTM1. Acts as a negative regulator of autophagy by mediating palmitoylation of SQSTM1, decreasing affinity between SQSTM1 and ATG8 proteins and recruitment of ubiquitinated cargo proteins to autophagosomes. Acts as a lysophospholipase and hydrolyzes lysophosphatidylcholine (lyso-PC). Also hydrolyzes lysophosphatidylethanolamine (lyso-PE), lysophosphatidylinositol (lyso-PI) and lysophosphatidylserine (lyso-PS). Has much higher thioesterase activity than lysophospholipase activity. Contributes to the production of lysophosphatidic acid (LPA) during blood coagulation by recognizing and cleaving plasma phospholipids to generate lysophospholipids which in turn act as substrates for ENPP2 to produce LPA.
Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum
Cellular Componentnuclear membrane
Cellular Componentnucleolus
Cellular Componentplasma membrane
Cellular Componentribonucleoprotein complex
Molecular Functioncarboxylic ester hydrolase activity
Molecular Functionpalmitoyl-(protein) hydrolase activity
Biological Processprotein depalmitoylation
Biological ProcessrRNA processing

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    rRNA biogenesis protein RRP36

Gene names

    • ORF names
      TREES_T100010529

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Scandentia > Tupaiidae > Tupaia

Accessions

  • Primary accession
    L9LBF6

Proteomes

Subcellular Location

Keywords

PTM/Processing

Keywords

Interaction

Subunit

Associates with 90S and pre-40S pre-ribosomal particles.
Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, coiled coil.

Type
IDPosition(s)Description
Domain159-251Phospholipase/carboxylesterase/thioesterase
Coiled coil258-294

Sequence similarities

Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.
Belongs to the RRP36 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    348
  • Mass (Da)
    38,883
  • Last updated
    2013-04-03 v1
  • Checksum
    7960C8F3B86F0200
MTGFGMIYDPFDCAKKNEPKYYTYKTQPVGEEKDLKKTAPAARTERVEKIDRMSVVSGMLHITSQEISQNSDLNLIMSTIICFKFLHSVVTLACQGVLTSAASIAYSSQILPCIRHAINVLNKNTFDPGVTHAEEGPAGKVLKRVLVVSPRIRESAVPGGALSLYTALTTQQKLAGVTALSCWLPLRASFPQGPISGVNRDISILQCHGDCDPLVPLMFGSLTVEKLKTLVNPANVTFKTYEGMMHSSCQQYCPGEKHEKLQQLLQRMEQQEEAEQERKRQQELRLTLRQERRAQAQQGHRPYFLKKSEQRQLSQLTLAERFEKLKCITDSGTEEKGPVKAMASVHDS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KB320451
EMBL· GenBank· DDBJ
ELW71989.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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