L9KUM1 · L9KUM1_TUPCH

Function

function

Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation.

Catalytic activity

Cofactor

FAD (UniProtKB | Rhea| CHEBI:57692 )

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Functionalbendazole monooxygenase activity
Molecular Functionflavin adenine dinucleotide binding
Molecular Functionhypotaurine dehydrogenase activity
Molecular FunctionN,N-dimethylaniline monooxygenase activity
Molecular FunctionNADP binding
Molecular Functiontrimethylamine monooxygenase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Flavin-containing monooxygenase
  • EC number

Gene names

    • ORF names
      TREES_T100009741

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Scandentia > Tupaiidae > Tupaia

Accessions

  • Primary accession
    L9KUM1

Proteomes

Subcellular Location

Endoplasmic reticulum membrane
; Single-pass membrane protein
Microsome membrane
; Single-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane1129-1147Helical

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region688-719Disordered

Sequence similarities

Belongs to the FMO family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,150
  • Mass (Da)
    129,079
  • Last updated
    2013-04-03 v1
  • Checksum
    DBFCDEA6A04FE47A
MKLSVSSPTGTMSKRVAVIGAGVSGLAAIRSCLEEGLEPTCFERSNDIGGLWKFSTLVSSIKKCPSFLETGQWVIVTEKDGKQEFAVFDAVMVCSGHHVYPNLPTDSFPGLDKFQGSHFHSRDYKGGKRVLVIGLGNSGSDIAVELSHLATQVIISTRSGSWVMSRVWDDGYPWDMLYVTRFASFLRNILPSFVSDWLYVKKMNTWFKHENYGLMPLNGPLRKEPVFNDELPARILCGTVSIKPNVKEFTETAAIFEDGTVFKDIDCVIFATGYSYAYPFLDDSIIKSRNNEVTLFKGIFPPLMEKPTLAVIGLVQSLGAAIPTADLQARWAAKVFANLCTLPTTNEMMDDIDEKMGKKLKWFGQSQTLQTDYITYMDELGSFIGAKPSVLWLLLTDPRLAMEVYFGPCSPYQFRLMGPGKWDGARNAILTQWDRTVKPTRTRTVETKVPFLILMSLSWRNGKSPGPGMGSSSGRARGGQETMTKKVAVIGAGVSGLISLKCCVDEGLEPICFERTEDIGGLWRFKENVEDGRASIYQSVITNTSKEMSCFSDFPMPEDFPNFLHNSKLLEYFRIFSTKFDLRKYIQFQTTVLTVKRRPDFPSSGQWEVVTESNGRERSAVFDAVMVCSGHHILPHIPLKSFPGIERFKGQYFHSRQYKHPDGFERNRILVIGIGNSASDIAVELSRRAAQVQRPPTQGDGTGKRAVEKQRKDSTELPQGLTLPGVGDVAEVIGNGRTRIPSGRTVSGIGFEMPPSKHDDPPHCPQVFISTRQGSWVMSRISEDGYPWDMVFHTRFSSTLRNVLPRTALKWMMERQMNRWFNHENYGLEPQNKYLMKEPVLNDDLPSRLLYGAIKVKPRVKELTETSAIFEDDTEENIDVIVFATGYTFSFPFLEDSLVQVEDNMVSLYKYIFPPHLEKSTLACIGLIQPLGSIFPTVELQARWVTRVFKDSLVQVEDNMVSLYKYIFPPHLEKSTLACIGLIQPLGSIFPTVELQARWVTRVFKVQVQTLLHGQSQNAGMAAPGAQQHGSADRFGESQSQILQTNYIDYLDELASEIGAKPDFASLLLRDPTLAVKLYFGPCNSYQYRLAGPGRWDGARDAIFTQKQRILKPLKTRALRTSSHCPVSSLWKILGLLAVIVAFFFPLQWS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KB320645
EMBL· GenBank· DDBJ
ELW66620.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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