L8YCQ4 · L8YCQ4_TUPCH

Function

function

Catalyzes the three sequential steps of the methylation pathway for the biosynthesis of phosphatidylcholine, a critical and essential component for membrane structure. Uses S-adenosylmethionine (S-adenosyl-L-methionine, SAM or AdoMet) as the methyl group donor for the methylation of phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE) to phosphatidylmonomethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine, PMME), PMME to phosphatidyldimethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine, PDME), and PDME to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), producing S-adenosyl-L-homocysteine in each step.

Catalytic activity

Pathway

Lipid metabolism.
Phospholipid metabolism; phosphatidylcholine biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site124-126S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site206-207S-adenosyl-L-methionine (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Cellular Componentmitochondrial membrane
Molecular Functionphosphatidyl-N-methylethanolamine N-methyltransferase activity
Molecular Functionphosphatidylethanolamine N-methyltransferase activity
Biological Processmethylation
Biological Processphosphatidylcholine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphatidylethanolamine N-methyltransferase
  • EC number
  • Short names
    PEAMT
    ; PEMT
  • Alternative names
    • Phospholipid methyltransferase
      (PLMT
      )

Gene names

    • Name
      PEMT
    • ORF names
      TREES_T100005663

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Scandentia > Tupaiidae > Tupaia

Accessions

  • Primary accession
    L8YCQ4

Proteomes

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein
Mitochondrion membrane
; Multi-pass membrane protein
Note: Found in endoplasmic reticulum where most PEMT activity is generated and in mitochondria.

Features

Showing features for topological domain, intramembrane, transmembrane.

TypeIDPosition(s)Description
Topological domain1-38Lumenal
Intramembrane39-59Helical
Transmembrane41-58Helical
Topological domain60-71Lumenal
Topological domain93-119Cytoplasmic
Transmembrane120-145Helical
Topological domain141-183Lumenal
Transmembrane188-205Helical
Topological domain205-225Cytoplasmic

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    225
  • Mass (Da)
    24,967
  • Last updated
    2013-04-03 v1
  • Checksum
    F5D7ADD1E92FC1C0
MSSSAAGPDCCGGLGNIDFRKADLCVMTRLLGYVDLWEPRFVAAVLATAFNPLFWNVVARWEHRTRKLSRAFRSPHLACYFLGGAILLLNVLRSHCFTQAMLSQPQMESLDNPTAYRLGLAFLGVGVVLVLSSFFALGFTGTFLGDYFGILKEARVTSFPFNVLDNPMYWGSTANYLGWALMHASPSGLLLAAVVGLIYMVAILYEEPFTTEIYQRKASESHRRS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KB359564
EMBL· GenBank· DDBJ
ELV14007.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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