L8IKQ5 · L8IKQ5_9CETA

  • Protein
    Cyclin-dependent kinase 5 activator
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    5/5

Function

function

p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-BMAL1 heterodimer in association with altered stability and subcellular distribution.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcyclin-dependent protein kinase holoenzyme complex
Cellular Componentgrowth cone
Cellular Componentnucleoplasm
Cellular Componentperikaryon
Cellular Componentperinuclear region of cytoplasm
Cellular Componentplasma membrane
Cellular Componentprotein kinase 5 complex
Molecular Functionactin filament binding
Molecular Functioncyclin-dependent protein serine/threonine kinase activator activity
Molecular Functionionotropic glutamate receptor binding
Molecular Functionkinase activity
Molecular Functionprotease binding
Molecular Functionprotein kinase binding
Biological Processaxon guidance
Biological Processaxonal fasciculation
Biological Processcerebellum development
Biological Processephrin receptor signaling pathway
Biological ProcessG1 to G0 transition involved in cell differentiation
Biological Processhippocampus development
Biological Processlayer formation in cerebral cortex
Biological Processnegative regulation of DNA-templated transcription
Biological Processneuron cell-cell adhesion
Biological Processneuron migration
Biological Processpeptidyl-serine phosphorylation
Biological Processpeptidyl-threonine phosphorylation
Biological Processpositive regulation of protein targeting to membrane
Biological Processregulation of actin cytoskeleton organization
Biological Processregulation of dendritic spine morphogenesis
Biological Processregulation of microtubule cytoskeleton organization
Biological Processrhythmic process
Biological Processsuperior olivary nucleus maturation

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cyclin-dependent kinase 5 activator

Gene names

    • ORF names
      E5288_WYG020630
      , M91_10428

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • YakQH1
    • yakQH1
    • WY2019
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos

Accessions

  • Primary accession
    L8IKQ5

Proteomes

Subcellular Location

Keywords

PTM/Processing

Keywords

Interaction

Subunit

Heterodimer composed of a catalytic subunit CDK5 and a regulatory subunit CDK5R1 (p25) and macromolecular complex composed of at least CDK5, CDK5R1 (p35) and CDK5RAP1 or CDK5RAP2 or CDK5RAP3. Only the heterodimer shows kinase activity. Interacts with EPHA4 and NGEF; may mediate the activation of NGEF by EPHA4. Interacts with RASGRF2. The complex p35/CDK5 interacts with CLOCK.
Heterodimer of a catalytic subunit and a regulatory subunit.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias.

Type
IDPosition(s)Description
Region97-135Disordered
Compositional bias111-129Polar residues

Sequence similarities

Belongs to the cyclin-dependent kinase 5 activator family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    307
  • Mass (Da)
    34,088
  • Last updated
    2013-04-03 v1
  • Checksum
    738F24F3F458EE68
MGTVLSLSPSYRKATLFEDGAATVGHYTAVQNSKNAKDKNLKRHSIISVLPWKRIVAVSAKKKNSKKVQPNSSYQNNITHLNNENLKKSLSCANLSTFAQPPPAQPPAPPASQLSGSQTGVSSSVKKAPHPAVSSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYMGNEISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKRLLLGLDR

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias111-129Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JH881209
EMBL· GenBank· DDBJ
ELR55712.1
EMBL· GenBank· DDBJ
Genomic DNA
VBQZ03000021
EMBL· GenBank· DDBJ
MXQ84536.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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