L8HYQ3 · L8HYQ3_9CETA

  • Protein
    mRNA decay activator protein ZFP36
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Predicted
  • Annotation score
    5/5

Function

function

Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Cellular ComponentP-body
Cellular Componentribonucleoprotein complex
Molecular Function14-3-3 protein binding
Molecular Functionmetal ion binding
Molecular FunctionmRNA 3'-UTR AU-rich region binding
Biological Process3'-UTR-mediated mRNA destabilization
Biological Processapoptotic process
Biological Processcell population proliferation
Biological Processcellular response to cAMP
Biological Processcellular response to epidermal growth factor stimulus
Biological Processcellular response to fibroblast growth factor stimulus
Biological Processcellular response to glucocorticoid stimulus
Biological Processcellular response to hypoxia
Biological Processcellular response to insulin stimulus
Biological Processcellular response to raffinose
Biological Processcellular response to salt stress
Biological Processcellular response to transforming growth factor beta stimulus
Biological Processcellular response to tumor necrosis factor
Biological Processchorio-allantoic fusion
Biological ProcessERK1 and ERK2 cascade
Biological Processheart development
Biological Processmesendoderm development
Biological ProcessmRNA transport
Biological Processmulticellular organism growth
Biological Processnegative regulation of erythrocyte differentiation
Biological Processnegative regulation of mitotic cell cycle phase transition
Biological Processneural tube development
Biological Processnuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
Biological Processp38MAPK cascade
Biological Processphosphatidylinositol 3-kinase/protein kinase B signal transduction
Biological Processpositive regulation of fat cell differentiation
Biological Processpositive regulation of intracellular mRNA localization
Biological Processpositive regulation of monocyte differentiation
Biological Processpositive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
Biological Processproepicardium development
Biological Processregulation of B cell differentiation
Biological Processregulation of keratinocyte apoptotic process
Biological Processregulation of keratinocyte differentiation
Biological Processregulation of keratinocyte proliferation
Biological Processregulation of mRNA 3'-end processing
Biological Processregulation of myoblast differentiation
Biological Processregulation of stem cell proliferation
Biological Processregulation of translation
Biological Processresponse to wounding
Biological Processspongiotrophoblast layer development
Biological ProcessT cell differentiation in thymus
Biological Processvasculogenesis

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    mRNA decay activator protein ZFP36
  • Alternative names
    • Zinc finger protein 36

Gene names

    • ORF names
      E5288_WYG012591
      , M91_10584

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • yakQH1
    • YakQH1
    • WY2019
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos

Accessions

  • Primary accession
    L8HYQ3

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, domain, zinc finger, compositional bias.

Type
IDPosition(s)Description
Region72-113Disordered
Domain114-142C3H1-type
Zinc finger114-142C3H1-type
Domain152-180C3H1-type
Zinc finger152-180C3H1-type
Region273-338Disordered
Compositional bias289-338Polar residues

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    338
  • Mass (Da)
    36,370
  • Last updated
    2013-04-03 v1
  • Checksum
    928BC73D39595F68
MTTTLVSATIFDLSEVLCKGNKMLNYSTPSAGGCLLDRKAVGTPAGGGFPRRHSVTLPSSKFHQNQLLSSLKGEPAPALSSRDSRFRDRSFSEGGERLLPPQKQPGSGQVNSSRYKTELCRPFEENGACKYGDKCQFAHGIHELRSLTRHPKYKTELCRTFHTIGFCPYGPRCHFIHNAEERRALAGARDLSADRPRLQHSFSFAGFPSAAATAAATGLLDSPTSITPPPILSADDLLGSPTLPDGTNNPFAFSSQELASLFAPSMGLPGGGSPTTFLFRPMSESPHMFDSPPSPQDSLSDQEGYLSSSSSSHSGSDSPTLDNSRRLPIFSRLSISDD

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias289-338Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JH882530
EMBL· GenBank· DDBJ
ELR49063.1
EMBL· GenBank· DDBJ
Genomic DNA
VBQZ03000136
EMBL· GenBank· DDBJ
MXQ95481.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help