L8HXR1 · L8HXR1_9CETA

Function

function

May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. Mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcaveola
Cellular Componentdystrophin-associated glycoprotein complex
Cellular Componentendoplasmic reticulum
Cellular Componentfocal adhesion
Cellular ComponentGolgi membrane
Cellular Componentsarcolemma
Molecular Functioncalcium channel regulator activity
Molecular Functionconnexin binding
Molecular Functionmolecular adaptor activity
Molecular Functionprotein-containing complex binding
Molecular Functionsodium channel regulator activity
Molecular Functiontransmembrane transporter binding
Biological Processcaveola assembly
Biological Processcell differentiation
Biological Processnegative regulation of calcium ion transport
Biological Processnegative regulation of cardiac muscle hypertrophy
Biological Processnegative regulation of cell size
Biological Processnegative regulation of MAPK cascade
Biological Processnegative regulation of sarcomere organization
Biological Processregulation of calcium ion import
Biological Processregulation of cardiac muscle cell action potential involved in regulation of contraction
Biological Processregulation of cytosolic calcium ion concentration
Biological Processregulation of heart rate
Biological Processregulation of membrane depolarization during cardiac muscle cell action potential
Biological Processregulation of nerve growth factor receptor activity
Biological Processregulation of signal transduction by receptor internalization
Biological Processregulation of skeletal muscle contraction
Biological Processregulation of sodium ion transmembrane transport
Biological Processregulation of ventricular cardiac muscle cell membrane depolarization
Biological Processregulation of ventricular cardiac muscle cell membrane repolarization

Names & Taxonomy

Protein names

  • Recommended name
    Caveolin

Gene names

    • ORF names
      M91_07202

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • yakQH1
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos

Accessions

  • Primary accession
    L8HXR1

Proteomes

Subcellular Location

Cell membrane, sarcolemma
Cell membrane
; Peripheral membrane protein
Golgi apparatus membrane
; Peripheral membrane protein
Membrane, caveola
; Peripheral membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane79-102Helical

Keywords

PTM/Processing

Keywords

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the caveolin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    151
  • Mass (Da)
    17,362
  • Last updated
    2013-04-03 v1
  • Checksum
    C68FCC1E58BA1023
MMAEEHTDLEAQIVKDIHFKEIDLVNRDPKNINEDIVKVDFEDVIAEPVGTYSFDGVWKVSYTTFTVSKYWCYRLLSTLLGVPLALLWGFLFACISFCHIWAVVPCIKSYLIEIQCISHIYSLCIRTFCNPLFAALGQVCSNIKVMLRKEV

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JH882856
EMBL· GenBank· DDBJ
ELR48099.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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