SPT6 acts as a master regulator of Pol II elongation favoring productive protein coding over non-productive and potentially deleterious lncRNA transcription.
cryo-EM structure of an activated elongation complex of Sus scrofa Pol II and Homo sapiens DSIF PAF and SPT6 was determined at 3.1 A resolution and compared to the structure of the paused elongation complex formed by Pol II DSIF and NELF
These results show that intracellular levels of Spt6 are fine-tuned by PAAF1 and proteasome which is required for HIV-1 transcription and extends to cellular genes implicated in cancer.
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