L8B5U8 · L8B5U8_GLOSP

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

Cu cation (UniProtKB | Rhea| CHEBI:23378 )

Note: Binds a copper A center.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular Functioncopper ion binding
Molecular Functioncytochrome-c oxidase activity
Biological ProcessATP synthesis coupled electron transport

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 2

Gene names

    • Name
      COX2

Encoded on

  • Mitochondrion

Organism names

Accessions

  • Primary accession
    L8B5U8

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane12-32Helical
Transmembrane52-74Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-80Cytochrome oxidase subunit II transmembrane region profile
Domain81-188Cytochrome oxidase subunit II copper A binding

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    188
  • Mass (Da)
    21,603
  • Last updated
    2013-04-03 v1
  • Checksum
    464E7A9A321D7D42
MEGIINFHHDLMFFLIVVTIFVCWMLFRVITLFDEKKNKVPSTIVHGATIEIIWTTIPALILLTVAIPSFALLYSMDEVIDPIITLKVIGSQWYWSYEYSDNLEFSDEPLIFDSYMVQENDLEIGQFRLLEVDNRVIVPTNSHIRVLITASDVLHSWAIPSLGVKLDACPGRLNQTSMFIKREGVFYG

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue188

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB780563
EMBL· GenBank· DDBJ
BAM77416.1
EMBL· GenBank· DDBJ
Genomic DNA
AB780564
EMBL· GenBank· DDBJ
BAM77417.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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