L7XP32 · L7XP32_HUMAN

  • Protein
    NADH-ubiquinone oxidoreductase chain 2
  • Gene
    ND2
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular FunctionNADH dehydrogenase (ubiquinone) activity
Biological Processmitochondrial electron transport, NADH to ubiquinone

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADH-ubiquinone oxidoreductase chain 2
  • EC number

Gene names

    • Name
      ND2

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    L7XP32

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane56-76Helical
Transmembrane96-115Helical
Transmembrane151-171Helical
Transmembrane178-196Helical
Transmembrane202-219Helical
Transmembrane239-257Helical
Transmembrane277-305Helical
Transmembrane325-346Helical

Keywords

PTM/Processing

Proteomic databases

Interaction

Subunit

Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. Interacts with TMEM242.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain23-284NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Domain290-344NADH dehydrogenase subunit 2 C-terminal

Sequence similarities

Belongs to the complex I subunit 2 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    347
  • Mass (Da)
    38,897
  • Last updated
    2013-04-03 v1
  • Checksum
    CE0F971D554C2402
MNPLAQPVIYSTIFAGTLITALSSHWFFTWVGLEMNMLAFIPVLTKKMNPRSTEAAIKYFLTQATASMILLMAILFNNMLSGQWTMTNTTNQYSSLMIMMAMAMKLGMAPFHFWVPEVTQGTPLTSGLLLLTWQKLAPISIMYQISPSLNVSLLLTLSILSIMAGSWGGLNQTQLRKILAYSSITHTGWMMAVLPYNPNMTILNLTIYIILTTTAFLLLNLNSSTTTLLLSRTWNKLTWLTPLIPSTLLSLGGLPPLTGFLPKWAIIEEFTKNNSLIIPTIMATITLLNLYFYLRLIYSTSITLLPMSNNVKMKWQFEHTKPTPLLPTLIALTTLLLPISPFMLMIL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KC345868
EMBL· GenBank· DDBJ
AGD83240.1
EMBL· GenBank· DDBJ
Genomic DNA
KC345873
EMBL· GenBank· DDBJ
AGD83305.1
EMBL· GenBank· DDBJ
Genomic DNA
KC345880
EMBL· GenBank· DDBJ
AGD83396.1
EMBL· GenBank· DDBJ
Genomic DNA
KC345882
EMBL· GenBank· DDBJ
AGD83422.1
EMBL· GenBank· DDBJ
Genomic DNA
KC345901
EMBL· GenBank· DDBJ
AGD83669.1
EMBL· GenBank· DDBJ
Genomic DNA
KC346093
EMBL· GenBank· DDBJ
AGD86165.1
EMBL· GenBank· DDBJ
Genomic DNA
KC346135
EMBL· GenBank· DDBJ
AGD86711.1
EMBL· GenBank· DDBJ
Genomic DNA
KC346136
EMBL· GenBank· DDBJ
AGD86724.1
EMBL· GenBank· DDBJ
Genomic DNA
KC346139
EMBL· GenBank· DDBJ
AGD86763.1
EMBL· GenBank· DDBJ
Genomic DNA
KC346141
EMBL· GenBank· DDBJ
AGD86789.1
EMBL· GenBank· DDBJ
Genomic DNA
KC346143
EMBL· GenBank· DDBJ
AGD86815.1
EMBL· GenBank· DDBJ
Genomic DNA
KC346170
EMBL· GenBank· DDBJ
AGD87166.1
EMBL· GenBank· DDBJ
Genomic DNA
KC346177
EMBL· GenBank· DDBJ
AGD87257.1
EMBL· GenBank· DDBJ
Genomic DNA
KF451538
EMBL· GenBank· DDBJ
AGZ73628.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ445742
EMBL· GenBank· DDBJ
AHX42701.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ669147
EMBL· GenBank· DDBJ
AIG60708.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ669148
EMBL· GenBank· DDBJ
AIG60721.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ669151
EMBL· GenBank· DDBJ
AIG60760.1
EMBL· GenBank· DDBJ
Genomic DNA
MK248369
EMBL· GenBank· DDBJ
QFV15579.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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