L7VHC7 · L7VHC7_MYCL1
- ProteinMultifunctional fusion protein
- GeneftsH
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids948 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
function
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
Catalytic activity
- GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H+
Cofactor
Note: Binds 1 zinc ion per subunit.
Pathway
Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 203-210 | ATP (UniProtKB | ChEBI) | |||
Binding site | 425 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Active site | 426 | ||||
Binding site | 429 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Binding site | 501 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Binding site | 836 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 839 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 909 | Zn2+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | ATP-dependent peptidase activity | |
Molecular Function | GTP binding | |
Molecular Function | GTP cyclohydrolase I activity | |
Molecular Function | metalloendopeptidase activity | |
Molecular Function | zinc ion binding | |
Biological Process | one-carbon metabolic process | |
Biological Process | protein catabolic process | |
Biological Process | proteolysis | |
Biological Process | tetrahydrofolate biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameMultifunctional fusion protein
Including 2 domains:
- Recommended nameGTP cyclohydrolase 1
- EC number
- Alternative names
- Recommended nameATP-dependent zinc metalloprotease FtsH
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacillati > Actinomycetota > Actinomycetes > Mycobacteriales > Mycobacteriaceae > Mycobacterium > Mycobacterium ulcerans group
Accessions
- Primary accessionL7VHC7
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 7-26 | Helical | |||
Transmembrane | 115-132 | Helical | |||
Keywords
- Cellular component
Interaction
Subunit
Homohexamer.
Homopolymer.
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 195-334 | AAA+ ATPase | |||
Region | 615-765 | Disordered | |||
Compositional bias | 749-761 | Polar residues | |||
Sequence similarities
Belongs to the AAA ATPase family.
Belongs to the GTP cyclohydrolase I family.
In the C-terminal section; belongs to the peptidase M41 family.
In the central section; belongs to the AAA ATPase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length948
- Mass (Da)103,003
- Last updated2013-04-03 v1
- MD5 Checksum632CDFBDB14D0963D99B15B7F6F9CB60
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 749-761 | Polar residues | |||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP003899 EMBL· GenBank· DDBJ | AGC64804.1 EMBL· GenBank· DDBJ | Genomic DNA |