L7VHC7 · L7VHC7_MYCL1

Function

function

Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site203-210ATP (UniProtKB | ChEBI)
Binding site425Zn2+ (UniProtKB | ChEBI); catalytic
Active site426
Binding site429Zn2+ (UniProtKB | ChEBI); catalytic
Binding site501Zn2+ (UniProtKB | ChEBI); catalytic
Binding site836Zn2+ (UniProtKB | ChEBI)
Binding site839Zn2+ (UniProtKB | ChEBI)
Binding site909Zn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionATP-dependent peptidase activity
Molecular FunctionGTP binding
Molecular FunctionGTP cyclohydrolase I activity
Molecular Functionmetalloendopeptidase activity
Molecular Functionzinc ion binding
Biological Processone-carbon metabolic process
Biological Processprotein catabolic process
Biological Processproteolysis
Biological Processtetrahydrofolate biosynthetic process

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Multifunctional fusion protein

Including 2 domains:

  • Recommended name
    GTP cyclohydrolase 1
  • EC number
  • Alternative names
    • GTP cyclohydrolase I
      (GTP-CH-I
      )
  • Recommended name
    ATP-dependent zinc metalloprotease FtsH
  • EC number

Gene names

    • Name
      ftsH
    • Synonyms
      folE
    • Ordered locus names
      MULP_05374

Organism names

  • Taxonomic identifier
  • Strain
    • 128FXT
  • Taxonomic lineage
    Bacteria > Bacillati > Actinomycetota > Actinomycetes > Mycobacteriales > Mycobacteriaceae > Mycobacterium > Mycobacterium ulcerans group

Accessions

  • Primary accession
    L7VHC7

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Membrane

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane7-26Helical
Transmembrane115-132Helical

Keywords

Interaction

Subunit

Homohexamer.
Homopolymer.

Structure

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain195-334AAA+ ATPase
Region615-765Disordered
Compositional bias749-761Polar residues

Sequence similarities

Belongs to the AAA ATPase family.
Belongs to the GTP cyclohydrolase I family.
In the C-terminal section; belongs to the peptidase M41 family.
In the central section; belongs to the AAA ATPase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    948
  • Mass (Da)
    103,003
  • Last updated
    2013-04-03 v1
  • MD5 Checksum
    632CDFBDB14D0963D99B15B7F6F9CB60
MNRKNVIRTVTAVAVVVVLGWSFFYFSDDTRGYKPVDTSVAMSQINADNVKSAQIDDREQQLRLVLKKSSSDTDGSDKVITKYPTGYAVDLFNALTAKNAKVSTVVNQGSILGELLVYVLPLLLLVGLFVMFSRMQGGARMGFGFGKSRAKQLSKDMPKTTFADVAGVDEAVEELYEIKDFLQNPSRYQALGAKIPKGVLLYGPPGTGKTLLARAVAGEAGVPFFTISGSDFVEMFVGVGASRVRDLFEQAKQNSPCIIFVDEIDAVGRQRGAGLGGGHDEREQTLNQLLVEMDGFGDRAGVILIAATNRPDILDPALLRPGRFDRQIPVTNPDLAGRRAVLRVHSKGKPIADGADLDGLAKRTVGMTGADLANVINEAALLTARENGTVITGPALEEAVDRVIGGPRRKGRIISEHEKKITAYHEGGHTLAAWAMPDIDPVYKVTILARGRTGGHAVAVPEEDKGLRTRSEMIAQLVFAMGGRAAEELVFREPTTGAVSDIEQATKVARAMVTEYGMSARLGAVKYGTEHGDPFLGRSMGTQSDYSHEVAREIDEEVRKLIEAAHTEAWEILTEYRDVLDTLAGQLLEKETLHRPELESIFSDVEKRPRLTMFDDFGGRIPSDKPPIKTPGELAIERGEPWPQPMPEPAFKQAIAQATQAARSASEGTGRGPNGSRGADANPGSHPDYGAPAGWRAPGWPPPSERPQPSGYSPDQPSDTDESSEQQDRDVSRSNPRPTADERRVAMTQLDSRTEATTTRAFDQPRAEAAVRELLLAIGEDPDRGGLRDTPARVARAYREIFAGLYTDPDAVLNTMFDEDHDELVLIKEIPLYSTCEHHLVSFHGVAHVGYIPGRDGRVTGLSKIARLVDLYAKRPQVQERLTSQIADALVKRLGPRGVIVVVEAEHLCMAMRGVRKPGAVTTTSAVRGQFKTDAASRAEALDLILRK

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias749-761Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP003899
EMBL· GenBank· DDBJ
AGC64804.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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