L7V5S0 · L7V5S0_MYCL1
- ProteinAdenosylcobinamide kinase
- GenecobU
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids186 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.
Catalytic activity
- adenosylcob(III)inamide + ATP = adenosylcob(III)inamide phosphate + ADP + H+
Pathway
Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 5/7.
Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 6/7.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 7-14 | GTP (UniProtKB | ChEBI) | ||||
Sequence: GGIRSGKS | ||||||
Binding site | 35-37 | GTP (UniProtKB | ChEBI) | ||||
Sequence: ASG | ||||||
Active site | 57 | GMP-histidine intermediate | ||||
Sequence: H | ||||||
Binding site | 58-61 | GTP (UniProtKB | ChEBI) | ||||
Sequence: RDRR | ||||||
Binding site | 69 | GTP (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 88 | GTP (UniProtKB | ChEBI) | ||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | adenosylcobinamide kinase (ATP-specific) activity | |
Molecular Function | adenosylcobinamide kinase (GTP-specific) activity | |
Molecular Function | ATP binding | |
Molecular Function | cobinamide phosphate guanylyltransferase activity | |
Molecular Function | GTP binding | |
Biological Process | cobalamin biosynthetic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAdenosylcobinamide kinase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Mycobacteriaceae > Mycobacterium > Mycobacterium ulcerans group
Accessions
- Primary accessionL7V5S0
Proteomes
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 33-66 | Disordered | ||||
Sequence: YLASGPATDSDSAASQDWDQRVARHRDRRPGHWS | ||||||
Compositional bias | 50-66 | Basic and acidic residues | ||||
Sequence: WDQRVARHRDRRPGHWS |
Sequence similarities
Belongs to the CobU/CobP family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length186
- Mass (Da)19,986
- Last updated2013-04-03 v1
- Checksum01599F332D3A7E98
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 50-66 | Basic and acidic residues | ||||
Sequence: WDQRVARHRDRRPGHWS |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP003899 EMBL· GenBank· DDBJ | AGC63161.1 EMBL· GenBank· DDBJ | Genomic DNA |